Počet záznamů: 1
Dairying, diseases and the evolution of lactase persistence in Europe
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SYSNO ASEP 0559942 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Dairying, diseases and the evolution of lactase persistence in Europe Tvůrce(i) Evershed, R. P. (GB)
Smith, G. D. (GB)
Roffet-Salque, M. (GB)
Timpson, A. (DE)
Brychová, Veronika (UJF-V) ORCID, SAI, RID
Vostrovská, I. (CZ)Celkový počet autorů 105 Zdroj.dok. Nature. - : Palgrave Macmillan - ISSN 0028-0836
Roč. 608, AUG (2022), s. 336-345Poč.str. 27 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova lactase persistence evolution ; organic residue analysis ; prehistorc milk exploitation Obor OECD Analytical chemistry Způsob publikování Omezený přístup Institucionální podpora UJF-V - RVO:61389005 UT WOS 000831072400001 EID SCOPUS 85135260134 DOI 10.1038/s41586-022-05010-7 Anotace In European and many African, Middle Eastern and southern Asian populations, lactase persistence (LP) is the most strongly selected monogenictrait to have evolved over the past 10,000 years(1). Although the selection of LP and the consumption of prehistoric milk must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions(2,3). Here we provide detailed distributions of milk exploitation across Europe over the past 9,000 years using around 7,000 pottery fat residues from more than 550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Notably, LP selection varying with levels of prehistoric milk exploitation is no better at explaining LP allele frequency trajectories than uniform selection since the Neolithic period. In the UK Biobank(4,5 )cohort of 500,000 contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests that other reasons for the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available but, under conditions of famine and/or increased pathogen exposure, this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model like lihoods indicates that population fluctuations, settlement density and wild animal exploitation-proxies for these drivers-provide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution. Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2023 Elektronická adresa https://doi.org/10.1038/s41586-022-05010-7
Počet záznamů: 1