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Metastatic spread inhibition of cancer cells through stimuli-sensitive HPMA copolymer-bound actinonin nanomedicines
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SYSNO ASEP 0559474 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Metastatic spread inhibition of cancer cells through stimuli-sensitive HPMA copolymer-bound actinonin nanomedicines Tvůrce(i) Kousalová, Jana (UMCH-V) RID, ORCID
Šírová, Milada (MBU-M) RID, ORCID
Kostka, Libor (UMCH-V) RID, ORCID
Šubr, Vladimír (UMCH-V) RID, ORCID
Kovářová, Jiřina (MBU-M)
Běhalová, Kateřina (MBU-M)
Studenovský, Martin (UMCH-V) RID, ORCID
Kovář, Marek (MBU-M) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCIDČíslo článku 102578 Zdroj.dok. Nanomedicine: Nanotechnology, Biology and Medicine. - : Elsevier - ISSN 1549-9634
Roč. 44, August (2022)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova matrix metalloproteinases ; metastases ; actinonin Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Vědní obor RIV – spolupráce Mikrobiologický ústav - Onkologie a hematologie CEP LTAUSA18083 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 ; MBU-M - RVO:61388971 UT WOS 000830513600002 EID SCOPUS 85133948215 DOI 10.1016/j.nano.2022.102578 Anotace The unresolved task of modern medicine is to prevent metastatic spread during and after the treatment of primary tumors. Here, the design, controlled synthesis, in-depth physicochemical and biological characteristics of a novel panel of well-defined water-soluble copolymer conjugates bearing actinonin intended for advanced drug delivery and inhibition of metastatic spread are described. Three different synthetic approaches were employed to covalently attach actinonin to the N-(2-hydroxypropyl)methacrylamide copolymers to control the release of actinonin to its pharmacologically active form. Actinonin was attached to the polymers via hydroxamate group suppressing its activity during the delivery, with the activity restored after its release in the primary tumors or metastatic foci. Importantly, developed nanosystems with favorable drug release kinetics inhibited the metastatic spread of cancer cells from primary 4T1 tumors into the lungs as well as invasion of B16F10 melanoma cells from circulation into the lungs at the dosage without any sign of toxicity. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S1549963422000648?via%3Dihub
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