Počet záznamů: 1
An Electrochemical Sensor for Detection of Neuroblastoma Markers: Complexation Studies as a Tool for the Selection of a Suitable Receptor for Electrode Coating
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SYSNO ASEP 0559102 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název An Electrochemical Sensor for Detection of Neuroblastoma Markers: Complexation Studies as a Tool for the Selection of a Suitable Receptor for Electrode Coating Tvůrce(i) Salvadori, Karolína (UCHP-M) RID, ORCID, SAI
Páleš, Jakub Marián (UCHP-M)
Shishkanova, T.V. (CZ)
Trchová, M. (CZ)
Fajgar, Radek (UCHP-M) RID, ORCID, SAI
Matějka, P. (CZ)
Cuřínová, Petra (UCHP-M) RID, SAI, ORCIDČíslo článku e202200165 Zdroj.dok. ChemPlusChem. - : Wiley - ISSN 2192-6506
Roč. 87, č. 8 (2022)Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova biosensors ; electropolymerization ; host-guest chemistry ; neuroblastoma markers Obor OECD Analytical chemistry CEP GA20-07833S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UCHP-M - RVO:67985858 UT WOS 000837730800001 EID SCOPUS 85135552513 DOI 10.1002/cplu.202200165 Anotace Homovanillate (HVA) and vanilmandelate (VMA) are recognized markers of diseases, including neuroblastoma. However, their detection in urine represents a challenging task due to the complexity of the matrix. Here, a design, synthesis and thorough investigation of polymerizable urea-based receptors interacting with HVA and VMA are reported. The selection of receptor with the best anion recognition properties for electrode coating is based on 1H NMR and UV-Vis complexation studies. The sensor is prepared by electropolymerization with progress monitoring by cyclic voltammetry. The deposited layer is characterized by IR and scanning electron microscopy. The obtained sensor shows an electrochemical impedance spectroscopy response to VMA with linear range 9.9×10-6 to 1.2×10-3 M and LOD of 3.4x10-6 M. The sensor selectivity was demonstrated by the determination of VMA level in the presence of 16 mM HVA and in artificial urine with and without phosphates, with standard deviations of 0.11, 0.17 and 0.09, respectively. Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2023 Elektronická adresa https://hdl.handle.net/11104/0332522
Počet záznamů: 1