Počet záznamů: 1
Silybin and its congeners: from traditional medicine to molecular effects
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SYSNO ASEP 0558662 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Silybin and its congeners: from traditional medicine to molecular effects Tvůrce(i) Křen, Vladimír (MBU-M) RID, ORCID
Valentová, Kateřina (MBU-M) RID, ORCIDZdroj.dok. Natural Product Reports. - : Royal Society of Chemistry - ISSN 0265-0568
Roč. 39, č. 6 (2022), s. 1264-1281Poč.str. 18 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova milk thistle ; silymarin flavonolignans ; in-vitro ; silibinin ; silychristin ; isosilybin ; 2,3-dehydrosilybin ; diastereoisomers ; identification ; derivatives Vědní obor RIV CE - Biochemie Obor OECD Medicinal chemistry CEP GA21-00551S GA ČR - Grantová agentura ČR LTC20070 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora MBU-M - RVO:61388971 UT WOS 000790828700001 EID SCOPUS 85133101119 DOI 10.1039/d2np00013j Anotace Covering: 2015 up to 2022 (Feb) Silymarin, an extract of milk thistle (Silybum marianum) fruits, has been used in various medicinal applications since ancient times. A major component of silymarin is the flavonolignan silybin and its relatives isosilybin, silychristin, silydianin, 2,3-dehydrosilybin, and some others. Except for silydianin, they occur in nature as two stereomers. This review focuses on recent developments in chemistry, biosynthesis, modern advanced analytical methods, and transformations of flavonolignans specifically reflecting their chirality. Recently described chemotypes of S. marianum, but also the newest findings regarding the pharmacokinetics, hepatoprotective, antiviral, neuroprotective, and cardioprotective activity, modulation of endocrine functions, modulation of multidrug resistance, and safety of flavonolignans are discussed. A growing number of studies show that the respective diastereomers of flavonolignans have significantly different activities in anisotropic biological systems. Moreover, it is now clear that flavonolignans do not act as antioxidants in vivo, but as specific ligands of biological targets and therefore their chirality is crucial. Many controversies often arise, mainly due to the non-standard composition of this phytopreparation, the use of various undefined mixtures, the misattribution of silymarin vs. silybin, and also the failure to consider the chemistry of the respective components of silymarin. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2023 Elektronická adresa https://pubs.rsc.org/en/content/articlelanding/2022/NP/D2NP00013J
Počet záznamů: 1