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The Tale-Tell Heart: Evolutionary tetrapod shift from aquatic to terrestrial life-style reflected in heart changes in axolotl (Ambystoma mexicanum)
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SYSNO ASEP 0558188 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The Tale-Tell Heart: Evolutionary tetrapod shift from aquatic to terrestrial life-style reflected in heart changes in axolotl (Ambystoma mexicanum) Tvůrce(i) Olejníčková, Veronika (FGU-C) RID, ORCID, SAI
Kolesová, Hana (FGU-C) RID, ORCID, SAI
Bartoš, M. (CZ)
Sedmera, David (FGU-C) RID, ORCID, SAI
Gregorovičová, Martina (FGU-C) RID, ORCID, SAIZdroj.dok. Developmental Dynamics. - : Wiley - ISSN 1058-8388
Roč. 251, č. 6 (2022), s. 1004-1014Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova atrial septation ; metamorphosis ; micro-CT ; optical mapping ; trabeculae ; ventricular septation Obor OECD Developmental biology Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000688505000001 EID SCOPUS 85113353000 DOI 10.1002/dvdy.413 Anotace Background During amphibian metamorphosis, the crucial moment lies in the rearrangement of the heart, reflecting the changes in circulatory demands. However, little is known about the exact shifts linked with this rearrangement. Here, we demonstrate such myocardial changes in axolotl (Ambystoma mexicanum) from the morphological and physiological point of view. Results Micro-CT and histological analysis showed changes in ventricular trabeculae organization, completion of the atrial septum and its connection to the atrioventricular valve. Based on Myosin Heavy Chain and Smooth Muscle Actin expression we distinguished metamorphosis-induced changes in myocardial differentiation at the ventricular trabeculae and atrioventricular canal. Using optical mapping, faster speed of conduction through the atrioventricular canal was demonstrated in metamorphic animals. No differences between the groups were observed in the heart rates, ventricular activation times, and activation patterns. Conclusions Transition from aquatic to terrestrial life-style is reflected in the heart morphology and function. Rebuilding of the axolotl heart during metamorphosis was connected with reorganization of ventricular trabeculae, completion of the atrial septum and its connection to the atrioventricular valve, and acceleration of AV conduction. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1002/dvdy.413
Počet záznamů: 1