Počet záznamů: 1
Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour Map Analysis and COVID-19 Therapeutics
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SYSNO ASEP 0557947 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour Map Analysis and COVID-19 Therapeutics Tvůrce(i) Selvaraj, C. (IN)
Dinesh, Dhurvas Chandrasekaran (UOCHB-X) ORCID
Krafčíková, Petra (UOCHB-X) ORCID
Bouřa, Evžen (UOCHB-X) ORCID
Aarthy, M. (IN)
Pravin, M. A. (IN)
Singh, S. K. (IN)Zdroj.dok. Current Molecular Pharmacology. - : Bentham Science Publishers - ISSN 1874-4672
Roč. 15, č. 2 (2022), s. 418-433Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. AE - Spojené arabské emiráty Klíč. slova SARS-CoV-2 ; COVID-19 ; repurposing ; FDA ; drug targets ; antivirales ; active site ; contour maps ; medicinal plants ; phytochemicals ; TCM ; natural products Obor OECD Virology CEP EF16_019/0000729 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000819380800009 EID SCOPUS 85130861775 DOI 10.2174/1874467214666210906125959 Anotace The pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is responsible for multiple worldwide lockdowns, an economic crisis, and a substantial increase in hospitalizations for viral pneumonia along with respiratory failure and multiorgan dys-functions. Recently, the first few vaccines were approved by World Health Organization (WHO) and can eventually save millions of lives. Even though, few drugs are used in emergency like Remdesivir and several other repurposed drugs, still there is no approved drug for COVID-19. The coronaviral encoded proteins involved in host-cell entry, replication, and host-cell invading mechanism are potential therapeutic targets. This perspective review provides the molecular overview of SARS-CoV-2 life cycle for summarizing potential drug targets, structural insights, active site contour map analyses of those selected SARS-CoV-2 protein targets for drug discovery, immunology, and pathogenesis. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2023 Elektronická adresa https://doi.org/10.2174/1874467214666210906125959
Počet záznamů: 1