Počet záznamů: 1
Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase
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SYSNO ASEP 0557890 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase Tvůrce(i) Brejchová, Kristýna (FGU-C) ORCID, RID, SAI
Palůchová, Veronika (FGU-C) ORCID, RID
Březinová, Marie (FGU-C) ORCID
Čajka, Tomáš (FGU-C) RID, ORCID, SAI
Balas, L. (FR)
Durand, T. (FR)
Křížová, M. (CZ)
Straňák, Z. (CZ)
Kuda, Ondřej (FGU-C) RID, ORCID, SAIČíslo článku 132983 Zdroj.dok. Food Chemistry. - : Elsevier - ISSN 0308-8146
Roč. 388, Sep 15 (2022)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova human breast milk ; lipidomics ; PAHSA ; colostrum ; elective caesarean section ; preterm birth Obor OECD Biochemistry and molecular biology CEP GA20-00317S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000803035900004 EID SCOPUS 85130638484 DOI 10.1016/j.foodchem.2022.132983 Anotace Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB), and term (preterm and term delivery) on the levels of lipokines in human milk at different stages of lactation. Metabolomic analysis of the milk identified triacylglycerol estolides as a metabolic reservoir of the anti-inflammatory lipid mediator 5-palmitic acid ester of hydroxystearic acid (5-PAHSA). We found that triacylglycerol estolides were substrates of carboxyl ester lipase and 5-PAHSA-containing lipids were the least preferred substrates among tested triacylglycerol estolide isomers. This explained exceptionally high colostrum levels of 5-PAHSA in the VB group. CS and preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic profiles normalized in mature milk. Mothers delivering term babies vaginally produce colostrum rich in 5-PAHSA, which could contribute to the prevention of intestinal inflammation in newborns. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1016/j.foodchem.2022.132983
Počet záznamů: 1