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Bladder microbiota are associated with clinical conditions that extend beyond the urinary tract
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SYSNO ASEP 0557760 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Bladder microbiota are associated with clinical conditions that extend beyond the urinary tract Tvůrce(i) Hrbáček, J. (CZ)
Tláskal, Vojtěch (BC-A) RID, ORCID
Čermák, P. (CZ)
Hanáček, V. (CZ)
Zachoval, R. (CZ)Číslo článku 874 Zdroj.dok. Microorganisms. - : MDPI
Roč. 10, č. 5 (2022)Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova aging ; antibiotics ; chronic kidney disease ; diabetes mellitus ; dyslipidemia ; erectile dysfunction ; smoking ; urinary microbiota Vědní obor RIV FE - Ostatní obory vnitřního lékařství Obor OECD Urology and nephrology Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 000801346700001 EID SCOPUS 85128591750 DOI 10.3390/microorganisms10050874 Anotace Background. Since the discovery of the human urinary microbiota (UM), alterations in microbial community composition have been associated with various genitourinary conditions. The aim of this exploratory study was to examine possible associations of UM with clinical conditions beyond the urinary tract and to test some of the conclusions from previous studies on UM. Methods. Catheterised urine samples from 87 men were collected prior to endoscopic urological interventions under anaesthesia. The composition of the bacterial community in urine was characterized using the hypervariable V4 region of the 16S rRNA gene. Samples from 58 patients yielded a sufficient amount of bacterial DNA for analysis. Alpha diversity measures (number of operational taxonomic units, ACE, iChao2, Shannon and Simpson indices) were compared with the Kruskal–Wallis test. Beta diversity (differences in microbial community composition) was assessed using non-metric dimensional scaling in combination with the Prevalence in Microbiome Analysis algorithm. Results. Differences in bacterial richness and diversity were observed for the following variables: age, diabetes mellitus, dyslipidemia, smoking status and single-dose preoperative antibiotics. Differences in microbial community composition were observed in the presence of chronic kidney disease, lower urinary tract symptoms and antibiotic prophylaxis. Conclusions. UM appears to be associated with certain clinical conditions, including those unrelated to the urinary tract. Further investigation is needed before conclusions can be drawn for diagnostics and treatment. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2023 Elektronická adresa https://www.mdpi.com/2076-2607/10/5/874
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