Počet záznamů: 1  

Nicotinic Acetylcholine Receptors Expressed by Striatal Interneurons Inhibit Striatal Activity and Control Striatal-Dependent Behaviors

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    SYSNO ASEP0557064
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevNicotinic Acetylcholine Receptors Expressed by Striatal Interneurons Inhibit Striatal Activity and Control Striatal-Dependent Behaviors
    Tvůrce(i) Abbondanza, Alice (FGU-C)
    Bas, Irina Ribeiro (FGU-C)
    Modrák, Martin (MBU-M) ORCID
    Čapek, Martin (FGU-C) RID, ORCID
    Minich, Jessica (FGU-C)
    Tyshkevich, Alexandra (FGU-C)
    Naser, Shahed (FGU-C)
    Rangotis, Revan (FGU-C)
    Houdek, Pavel (FGU-C)
    Sumová, Alena (FGU-C) RID, ORCID
    Dumas, S. (FR)
    Bernard, V. (FR)
    Janíčková, Helena (FGU-C) RID, ORCID, SAI
    Celkový počet autorů13
    Zdroj.dok.Journal of Neuroscience - ISSN 0270-6474
    Roč. 42, č. 13 (2022), s. 2786-2803
    Poč.str.18 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaacetylcholine ; behavior ; Fos ; interneurons ; nAChRs ; striatum
    Obor OECDNeurosciences (including psychophysiology
    CEPGJ19-07983Y GA ČR - Grantová agentura ČR
    LM2015062 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    LM2018129 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    8J21FR022 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    LM2018131 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    EF18_046/0016045 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    Institucionální podporaFGU-C - RVO:67985823 ; MBU-M - RVO:61388971
    UT WOS000779618200003
    EID SCOPUS85128160080
    DOI10.1523/JNEUROSCI.1627-21.2022
    AnotaceAcetylcholine is an important modulator of striatal activity, and it is vital to controlling striatal-dependent behaviors, including motor and cognitive functions. Despite this significance, the mechanisms determining how acetylcholine impacts striatal signaling are still not fully understood. In particular, little is known about the role of nAChRs expressed by striatal interneurons. In the present study, we used FISH to determine which neuronal types express the most prevalent beta2 nicotinic subunit in the mouse striatum. Our data support a common view that nAChR expression is mostly restricted to striatal interneurons. Surprisingly though, cholinergic interneurons were identified as a population with the highest expression of beta2 nicotinic subunit. To investigate the functional significance of beta2containing nAChRs in striatal interneurons, we deleted them by injecting the AAV-Cre vector into the striatum of beta2-flox/flox male mice. The deletion led to alterations in several behavioral domains, namely, to an increased anxiety-like behavior, decrease in sociability ratio, deficit in discrimination learning, and increased amphetamine-induced hyperlocomotion and c-Fos expression in mice with beta2 deletion. Further colocalization analysis showed that the increased c-Fos expression was present in both medium spiny neurons and presumed striatal interneurons. The present study concludes that, despite being relatively rare, beta2-containing nAChRs are primarily expressed in striatal neurons by cholinergic interneurons and play a significant role in behavior.
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2023
    Elektronická adresahttps://doi.org/10.1523/JNEUROSCI.1627-21.2022
Počet záznamů: 1