Počet záznamů: 1
Epoxylipids and soluble epoxide hydrolase in heart diseases
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SYSNO ASEP 0556810 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Epoxylipids and soluble epoxide hydrolase in heart diseases Tvůrce(i) Imig, J. D. (US)
Červenka, L. (CZ)
Neckář, Jan (FGU-C) RID, ORCIDČíslo článku 114866 Zdroj.dok. Biochemical Pharmacology. - : Elsevier - ISSN 0006-2952
Roč. 195, Jan (2022)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova eicosanoids ; cytochrome P450 ; soluble epoxide hydrolase ; hypertension ; heart failure ; myocardial infarction ; inflammation ; mitochondrial function ; coronary artery Obor OECD Physiology (including cytology) CEP GA18-03207S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000777271600005 EID SCOPUS 85120733144 DOI 10.1016/j.bcp.2021.114866 Anotace Cardiovascular and heart diseases are leading causes of morbidity and mortality. Coronary artery endothelial and vascular dysfunction, inflammation, and mitochondrial dysfunction contribute to progression of heart diseases such as arrhythmias, congestive heart failure, and heart attacks. Classes of fatty acid epoxylipids and their enzymatic regulation by soluble epoxide hydrolase (sEH) have been implicated in coronary artery dysfunction, inflammation, and mitochondrial dysfunction in heart diseases. Likewise, genetic and pharmacological manip-ulations of epoxylipids have been demonstrated to have therapeutic benefits for heart diseases. Increasing epoxylipids reduce cardiac hypertrophy and fibrosis and improve cardiac function. Beneficial actions for epox-ylipids have been demonstrated in cardiac ischemia reperfusion injury, electrical conductance abnormalities and arrhythmias, and ventricular tachycardia. This review discusses past and recent findings on the contribution of epoxylipids in heart diseases and the potential for their manipulation to treat heart attacks, arrhythmias, ven-tricular tachycardia, and heart failure. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1016/j.bcp.2021.114866
Počet záznamů: 1