Počet záznamů: 1
Peptides before and during the nucleotide world: An origins story emphasizing cooperation between proteins and nucleic acids
- 1.
SYSNO ASEP 0556704 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Peptides before and during the nucleotide world: An origins story emphasizing cooperation between proteins and nucleic acids Tvůrce(i) Fried, S. D. (US)
Fujishima, K. (JP)
Makarov, M. (CZ)
Cherepashuk, I. (CZ)
Hlouchová, Klára (UOCHB-X) ORCIDČíslo článku 20210641 Zdroj.dok. Journal of the Royal Society Interface. - : Royal Society Publishing - ISSN 1742-5689
Roč. 19, č. 187 (2022)Poč.str. 18 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova origins of life ; protein evolution ; prebiotic polymers ; early peptides Obor OECD Biochemistry and molecular biology Způsob publikování Open access Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000791277600002 EID SCOPUS 85124253830 DOI 10.1098/rsif.2021.0641 Anotace Recent developments in Origins of Life research have focused on substantiating the narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular weight, a paradigm that typically sidelines the roles of peptides. Nevertheless, the simple synthesis of amino acids, the facile nature of their activation and condensation, their ability to recognize metals and cofactors and their remarkable capacity to self-assemble make peptides (and their analogues) favourable candidates for one of the earliest functional polymers. In this mini-review, we explore the ramifications of this hypothesis. Diverse lines of research in molecular biology, bioinformatics, geochemistry, biophysics and astrobiology provide clues about the progression and early evolution of proteins, and lend credence to the idea that early peptides served many central prebiotic roles before they were encodable by a polynucleotide template, in a putative 'peptide-polynucleotide stage'. For example, early peptides and mini-proteins could have served as catalysts, compartments and structural hubs. In sum, we shed light on the role of early peptides and small proteins before and during the nucleotide world, in which nascent life fully grasped the potential of primordial proteins, and which has left an imprint on the idiosyncratic properties of extant proteins. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2023 Elektronická adresa https://doi.org/10.1098/rsif.2021.0641
Počet záznamů: 1