Počet záznamů: 1
Infantile status epilepticus disrupts myelin development
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SYSNO ASEP 0555873 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Infantile status epilepticus disrupts myelin development Tvůrce(i) Bencúrová, P. (CZ)
Laakso, H. (FI)
Salo, R. A. (FI)
Paasonen, E. (FI)
Manninen, E. (FI)
Paasonen, J. (FI)
Michaeli, S. (US)
Mangia, S. (US)
Bareš, M. (CZ)
Brázdil, M. (CZ)
Kubová, Hana (FGU-C) RID, ORCID
Gröhn, O. (FI)Číslo článku 105566 Zdroj.dok. Neurobiology of Disease. - : Elsevier - ISSN 0969-9961
Roč. 162, Jan (2022)Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova animal model ; status epilepticus ; temporal lobe epilepsy ; myelin development ; white matter integrity ; MRI ; histology ; thalamocortical connectivity Obor OECD Neurosciences (including psychophysiology CEP EF16_025/0007444 GA MZd - Ministerstvo zdravotnictví GA19-11931S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000726620000005 EID SCOPUS 85120319408 DOI https://doi.org/10.1016/j.nbd.2021.105566 Anotace Temporal lobe epilepsy (TLE) is the most prevalent type of epilepsy in adults, it often starts in infancy or early childhood. Although TLE is primarily considered to be a grey matter pathology, a growing body of evidence links this disease with white matter abnormalities. In this study, we explore the impact of TLE onset and progression in the immature brain on white matter integrity and development utilising the rat model of Li-pilocarpine-induced TLE at the 12th postnatal day (P). Diffusion tensor imaging (DTI) and Black-Gold II histology uncovered disruptions in major white matter tracks (corpus callosum, internal and external capsules, and deep cerebral white matter) spreading through the whole brain at P28. These abnormalities were mostly not present any longer at three months after TLE induction, with only limited abnormalities detectable in the external capsule and deep cerebral white matter. Relaxation Along a Fictitious Field in the rotating frame of rank 4 indicated that white matter changes observed at both timepoints, P28 and P72, are consistent with decreased myelin content. The animals affected by TLE-induced white matter abnormalities exhibited increased functional connectivity between the thalamus and medial prefrontal and somatosensory cortex in adulthood. Furthermore, histological analyses of additional animal groups at P15 and P18 showed only mild changes in white matter integrity, suggesting a gradual age-dependent impact of TLE progression. Taken together, TLE progression in the immature brain distorts white matter development with a peak around postnatal day 28, followed by substantial recovery in adulthood. This developmental delay might give rise to cognitive and behavioural comorbidities typical for earlyonset TLE. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1016/j.nbd.2021.105566
Počet záznamů: 1