Počet záznamů: 1
Incorporation of fibrin, platelets, and red blood cells into a coronary thrombus in time and space
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SYSNO ASEP 0554916 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Incorporation of fibrin, platelets, and red blood cells into a coronary thrombus in time and space Tvůrce(i) Malý, M. (CZ)
Riedel, Tomáš (UMCH-V) RID, ORCID
Štikarová, J. (CZ)
Suttnar, J. (CZ)
Kotlín, R. (CZ)
Hajsl, M. (CZ)
Toušek, P. (CZ)
Kaufmanová, J. (CZ)
Kucerka, O. (CZ)
Weisel, J. W. (US)
Dyr, J. E. (CZ)Zdroj.dok. Thrombosis and Haemostasis. - : Georg Thieme Verlag - ISSN 0340-6245
Roč. 122, č. 3 (2022), s. 434-444Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova coronary ; aspiration thrombectomy ; scanning electron microscopy Vědní obor RIV FD - Onkologie a hematologie Obor OECD Hematology CEP GBP205/12/G118 GA ČR - Grantová agentura ČR GA19-02739S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000718575700002 EID SCOPUS 85119970139 DOI 10.1055/s-0041-1739193 Anotace We describe the internal structure, spatial organization and dynamic formation of coronary artery thrombi from ST-segment elevation myocardial infarction patients. Scanning electron microscopy (SEM) revealed significant differences among four groups of patients (<2 hours, 2–6 hours, 6–12 hours, and >12 hours) related to the time of ischemia. Coronary artery thrombi from patients presenting less than 2 hours after the infarction were almost entirely composed of platelets, with small amounts of fibrin and red blood cells. In contrast, thrombi from late presenters (>12 hours) consisted of mainly platelets at the distal end, where clotting was initiated, with almost no platelets at the proximal end, while the red blood cell content went from low at the initiating end to more than 90% at the proximal end. Furthermore, fibrin was present mainly on the outside of the thrombi and older thrombi contained thicker fibers. The red blood cells in late thrombi were compressed to a close-packed, tessellated array of polyhedral structures, called polyhedrocytes. Moreover, there was redistribution from the originally homogeneous composition to fibrin and platelets to the outside, with polyhedrocytes on the interior. The presence of polyhedrocytes and the redistribution of components are signs of in vivo clot contraction (or retraction). These results suggest why later thrombi are resistant to fibrinolytic agents and other treatment modalities, since the close-packed polyhedrocytes form a nearly impermeable seal. Furthermore, it is of particular clinical significance that these findings suggest specific disparate therapies that will be most effective at different stages of thrombus development. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0041-1739193
Počet záznamů: 1