Počet záznamů: 1
Non-Enzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces
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SYSNO ASEP 0554850 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Non-Enzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces Tvůrce(i) Šponer, Judit E. (BFU-R) RID, ORCID
Šponer, Jiří (BFU-R) RID, ORCID
Výravský, J. (CZ)
Šedo, O. (CZ)
Zdráhal, Z. (CZ)
Costanzo, G. (IT)
Di Mauro, E. (IT)
Wunnava, S. (DE)
Braun, D. (DE)
Matyášek, Roman (BFU-R) ORCID
Kovařík, Aleš (BFU-R) RID, ORCIDCelkový počet autorů 11 Zdroj.dok. CHEMSYSTEMSCHEM. - : Wiley
Roč. 3, č. 6 (2021)Poč.str. 10 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova long prebiotic oligomers ; origin ; oligonucleotides ; crystal ; life Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP GA19-03442S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora BFU-R - RVO:68081707 UT WOS 000671941700001 DOI 10.1002/syst.202100017 Anotace Previous studies on the polymerization of 3',5' cyclic guanosine monophosphate (cGMP) demonstrated the potential of the compound in the abiotic generation of the first oligonucleotide sequences on the early Earth. These experiments were conducted under idealized laboratory conditions, which logically raises the question whether the same chemistry could take place in the harsh environment present on our planet in its earliest days. In the current study, we focus on the mineralogical context of this chemistry and show that numerous, but not all, common minerals assumed to be present on the early Earth could host the polymerization of H-form 3',5' cGMP. In particular, we have found that quartz varieties are especially suitable for this purpose, similar to andalusite, amphibole or micas. On the contrary, olivine, calcite, and serpentine-group minerals interfere with the studied polymerization chemistry. Our results show that crystallization on mineral surfaces, which is mainly a diffusion controlled process, determines the ability of 3',5' cGMP to polymerize. The observation that numerous amorphous and crystalline SiO2 forms are compatible with the oligomerization chemistry suggests that the process could commonly occur in a wide range of primordial environments allowing for crystallization of the cyclic monomers from a dropping solution. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2022 Elektronická adresa https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/syst.202100017
Počet záznamů: 1