Počet záznamů: 1
Modular Synthesis of Dendritic Amphiphiles.
- 1.
SYSNO ASEP 0553686 Druh ASEP A - Abstrakt Zařazení RIV Záznam nebyl označen do RIV Zařazení RIV Není vybrán druh dokumentu Název Modular Synthesis of Dendritic Amphiphiles. Tvůrce(i) Edr, Antonín (UCHP-M) ORCID, RID, SAI
Kalasová, J. (CZ)
Malý, J. (CZ)
Strašák, Tomáš (UCHP-M) RID, ORCID, SAIZdroj.dok. Czech Chemial Society Symposium Series, Vol 19, No 1. - Praha : Česká společnost chemická, 2021 / Řápková R. ; Fusek M. ; Drašar P. - ISSN 2336-7202
S. 12-13Poč.str. 2 s. Forma vydání Online - E Akce Interdisciplinary Meeting of Young Biologists, Biochemists and Chemists /20./ on-line meeting Datum konání 17.05.2021 - 20.05.2021 Země CZ - Česká republika Typ akce EUR Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova modular synthesis ; dendritic amphiphiles ; dendrons Vědní obor RIV CC - Organická chemie Obor OECD Organic chemistry Institucionální podpora UCHP-M - RVO:67985858 Anotace Among nanovesicle drug delivery systems, liposomes are the oldest and most widely used
vehicles. To overcome some of their drawbacks, analogical supramolecular systems based on
different building blocks were developed in two recent decades. Next to polymersomes or
exosomes, an attention is turned to so-called dendrimersomes.3,4 Dendrimersomes are
nanovesicles most usually self-assembled from so-called Janus dendrimers. These dendrimers
consist of two different dendrons, where one bears lipophilic groups on its periphery and one
bears polar groups. Following dendrimersomes design, this project aims on preparation of
similar nanovesicles from amphiphilic molecules with one dendritic positively charged part and
one part formed by linear lipophilic alkyl chains as in the case of building blocks of liposomes. In the aqueous solution, these amphiphiles should be able to self-assemble into supramolecular objects. These supramolecular objects could then serve as nanovehicles for variety of drugs or nucleic acids with therapeutic effects. The project is specially focused on delivery of siRNA (short interfering RNA).Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2022
Počet záznamů: 1