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Vascular response on a novel fibrin-based coated flow diverter
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SYSNO ASEP 0552896 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Vascular response on a novel fibrin-based coated flow diverter Tvůrce(i) Mühl-Benninghaus, R. (DE)
Fries, F. (DE)
Kießling, M. (DE)
Tomori, T. (DE)
Krajewski, S. (DE)
Simgen, A. (DE)
Bauer, S. (DE)
Hey, N. (DE)
Brynda, Eduard (UMCH-V) RID
Táborská, Johanka (UMCH-V)
Riedel, Tomáš (UMCH-V) RID, ORCID
Reith, W. (DE)
Cattaneo, G. (DE)
Brochhausen, C. (DE)Zdroj.dok. Cardiovascular and Interventional Radiology. - : Springer - ISSN 0174-1551
Roč. 45, č. 2 (2022), s. 236-243Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova flow diverter ; coating ; surface modification Vědní obor RIV EI - Biotechnologie a bionika Obor OECD Biomaterials (as related to medical implants, devices, sensors) CEP GA18-01163S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000730878700001 EID SCOPUS 85121375179 DOI 10.1007/s00270-021-03007-9 Anotace Purpose: Due to thromboembolic complications and in-stent-stenosis after flow diverter (FD) treatment, the long-term use of dual antiplatelet treatment (DAPT) is mandatory. The tested nano-coating has been shown to reduce material thrombogenicity and promote endothelial cell proliferation in vitro. We compared the biocompatibility of coated (Derivo Heal) and non-coated (Derivo bare) FDs with DAPT in an animal model. Methods: Derivo® bare (n = 10) and Derivo® Heal (n = 10) FD were implanted in the common carotid arteries (CCAs) of New Zealand white rabbits. One additional FD, alternately a Derivo bare (n = 5) or Derivo Heal (n = 5), was implanted in the abdominal aorta (AA) for assessment of the patency of branch arteries. Histopathological examinations were performed after 28 days. Angiography was performed before and after FD implantation and at follow-up. Results: Statistical analysis of the included specimens showed complete endothelialization of all FDs with no significant differences in neointima thickness between Derivo® bare and Derivo® Heal (CCA: p = 0.91, AA: p = 0.59). A significantly reduced number of macrophages in the vessel wall of the Derivo Heal was observed for the CCA (p = 0.02), and significantly reduced fibrin and platelet deposition on the surface of the Derivo Heal was observed for the AA. All branch arteries of the stented aorta remained patent.
Conclusion: In this animal model, the novel fibrin-based coated FD showed a similar blood and tissue compatibility as the non-coated FD.Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://link.springer.com/article/10.1007/s00270-021-03007-9
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