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Biodegradable thermoplastic starch/polycaprolactone blends with co-continuous morphology suitable for local release of antibiotics
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SYSNO ASEP 0552875 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Biodegradable thermoplastic starch/polycaprolactone blends with co-continuous morphology suitable for local release of antibiotics Tvůrce(i) Gajdošová, Veronika (UMCH-V) RID, ORCID
Strachota, Beata (UMCH-V) RID
Strachota, Adam (UMCH-V) RID, ORCID
Michálková, Danuše (UMCH-V)
Krejčíková, Sabina (UMCH-V)
Fulín, P. (CZ)
Nyč, O. (CZ)
Břínek, A. (CZ)
Zemek, M. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCIDČíslo článku 1101 Zdroj.dok. Materials. - : MDPI
Roč. 15, č. 3 (2022)Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova thermoplastic starch ; poly(ε-caprolactone) ; polymer blends Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP TN01000008 GA TA ČR - Technologická agentura ČR NU21-06-00084 GA MZd - Ministerstvo zdravotnictví GA19-04925S GA ČR - Grantová agentura ČR Výzkumná infrastruktura CzechNanoLab - 90110 - Vysoké učení technické v Brně Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000760870800001 EID SCOPUS 85123610917 DOI 10.3390/ma15031101 Anotace We report a reproducible preparation and characterization of highly homogeneous thermoplastic starch/pol(ε‑caprolactone) blends (TPS/PCL) with a minimal thermomechanical degradation and co-continuous morphology. These materials would be suitable for biomedical applications, specifically for the local release of antibiotics (ATB) from the TPS phase. The TPS/PCL blends were prepared in the whole concentration range. In agreement with theoretical predictions based on component viscosities, the co-continuous morphology was found for TPS/PCL blends with a composition of 70/30 wt.%. The minimal thermomechanical degradation of the blends was achieved by an optimization of the processing conditions and by keeping processing temperatures as low as possible, because higher temperatures might damage ATB in the final application. The blends’ homogeneity was verified by scanning electron microscopy. The co-continuous morphology was confirmed by submicron-computed tomography. The mechanical performance of the blends was characterized in both microscale (by an instrumented microindentation hardness testing, MHI) and macroscale (by dynamic thermomechanical analysis, DMTA). The elastic moduli of TPS increased ca four times in the TPS/PCL (70/30) blend. The correlations between elastic moduli measured by MHI and DMTA were very strong, which implied that, in the future studies, it would be possible to use just micromechanical testing that does not require large specimens. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://www.mdpi.com/1996-1944/15/3/1101
Počet záznamů: 1