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Age-Dependent Changes in the Function of Mitochondrial Membrane Permeability Transition Pore in Rat Liver Mitochondria

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    SYSNO ASEP0552140
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevAge-Dependent Changes in the Function of Mitochondrial Membrane Permeability Transition Pore in Rat Liver Mitochondria
    Tvůrce(i) Endlicher, R. (CZ)
    Drahota, Zdeněk (FGU-C) RID, ORCID
    Kučera, O. (CZ)
    Červinková, Z. (CZ)
    Zdroj.dok.Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
    Roč. 70, č. 6 (2021), s. 905-911
    Poč.str.7 s.
    Jazyk dok.eng - angličtina
    Země vyd.CZ - Česká republika
    Klíč. slovarat liver mitochondria ; mitochondrial permeability transition pore ; calcium retention capacity ; calcium-induced swelling
    Obor OECDPhysiology (including cytology)
    Způsob publikováníOpen access
    Institucionální podporaFGU-C - RVO:67985823
    UT WOS000735395600009
    EID SCOPUS85122449375
    DOI10.33549/physiolres.934734
    AnotaceMitochondria play an important role in the cell aging process. Changes in calcium homeostasis and/or increased reactive oxygen species (ROS) production lead to the opening of mitochondrial permeability transition pore (MPTP), depolarization of the inner mitochondrial membrane, and decrease of ATP production. Our work aimed to monitor age-related changes in the Ca2+ ion effect on MPTP and the ability of isolated rat liver mitochondria to accumulate calcium. The mitochondrial calcium retention capacity (CRC) was found to be significantly affected by the age of rats. Measurement of CRC values of the rat liver mitochondria showed two periods when 3 to 17-week old rats were tested. 3-week and 17-week old rats showed lower CRC values than 7-week old animals. Similar changes were observed while testing calcium-induced swelling of rat liver mitochondria. These findings indicate that the mitochondrial energy production system is more resistant to calcium-induced MPTP opening accompanied by the damaging effect of ROS in adult rats than in young and aged animals.
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2022
    Elektronická adresahttps://www.biomed.cas.cz/physiolres/pdf/2021/70_905.pdf
Počet záznamů: 1