Počet záznamů: 1
Polymeric Membranes Containing Iodine-Loaded UiO-66 Nanoparticles as Water-Responsive Antibacterial and Antiviral Surfaces
- 1.
SYSNO ASEP 0551583 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polymeric Membranes Containing Iodine-Loaded UiO-66 Nanoparticles as Water-Responsive Antibacterial and Antiviral Surfaces Tvůrce(i) Kirakci, Kaplan (UACH-T) SAI, RID, ORCID
Bůžek, Daniel (UACH-T) ORCID, RID, SAI
Peer, Petra (UH-J) ORCID, SAI, RID
Liška, V. (CZ)
Mosinger, Jiří (UACH-T) RID, ORCID, SAI
Křížová, I. (CZ)
Kloda, Matouš (UACH-T) SAI, RID, ORCID
Ondrušová, Soňa (UACH-T) RID, SAI
Lang, Kamil (UACH-T) SAI, RID, ORCID
Demel, Jan (UACH-T) SAI, RID, ORCIDCelkový počet autorů 10 Zdroj.dok. ACS Applied Nano Materials. - : American Chemical Society - ISSN 2574-0970
Roč. 5, č. 1 (2022), s. 1244-1251Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova metal-organic frameworks ; polymeric nanofibers ; membrane ; iodine ; antibacterial properties ; antiviral properties Vědní obor RIV CA - Anorganická chemie Obor OECD Inorganic and nuclear chemistry Vědní obor RIV – spolupráce Ústav pro hydrodynamiku - Ostatní materiály CEP GA19-09721S GA ČR - Grantová agentura ČR LM2018124 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UACH-T - RVO:61388980 ; UH-J - RVO:67985874 UT WOS 000736858900001 EID SCOPUS 85122568627 DOI 10.1021/acsanm.1c03832 Anotace The fight against pathogenic bacteria and viruses represents a challenging task requiring the development of innovative materials. The design of water-responsive disinfecting surfaces constitutes a pertinent endeavor to limit the spread of infectious pathogens that strive in wet environments and are often carried by the droplets or aerosols of biological fluids. In this context, we designed a polymeric nanostructured membrane which, when in contact with water, was able to release elemental iodine, a potent antimicrobial agent. The membrane was based on poly(vinylidene fluoride-co-hexafluoropropylene) electrospun nanofibers containing nanoparticles of an archetypal metal-organic framework (MOF), UiO-66. The gas adsorption capacity of the MOF container was preserved upon incorporation into the polymeric nanofibers, which also exerted a protective effect against the fast structural collapse of UiO-66 in phosphate-buffered saline, a model for biological fluids. The membrane loaded high amounts of iodine via gas diffusion and its release was (mostly) triggered by contact with the aqueous medium. The antibacterial activity of the membrane was tested against the Escherichia coli strain DH5 alpha and revealed prompt and robust disinfecting properties. The membrane also efficiently inhibited the infectivity of viral model vesicular stomatitis virus glycoprotein pseudotyped HIV-1 particles in HEK-293 cells in a short time. The observed synergistic effects between the MOF container and the polymeric support material constitute attractive features for the development of MOF-based materials for biological applications. Pracoviště Ústav anorganické chemie Kontakt Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Rok sběru 2023 Elektronická adresa https://doi.org/10.1021/acsanm.1c03832
Počet záznamů: 1