Počet záznamů: 1

Metabolomics atlas of oral 13C-glucose tolerance test in mice

SYSNO ASEP	0547418
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Metabolomics atlas of oral 13C-glucose tolerance test in mice
Tvůrce(i)	Lopes, Magno (FGU-C) Brejchová, Kristýna (FGU-C)_{ORCID, RID, SAI} Riečan, Martin (FGU-C)_ORCID Nováková, Michaela (FGU-C) Rossmeisl, Martin (FGU-C)_{RID, ORCID} Čajka, Tomáš (FGU-C)_{RID, ORCID, SAI} Kuda, Ondřej (FGU-C)_{RID, ORCID, SAI}
Číslo článku	109833
Zdroj.dok.	Cell Reports. - : Cell Press - ISSN 2211-1247 Roč. 37, č. 2 (2021)
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	metabolomics atlas ; metabolomics ; lipidomics ; glucose tolerance ; tracer analysis ; metabolite cycling ; brown adipose tissue ; 13C ; pathway analysis ; de novo lipogenesis
Vědní obor RIV	CE - Biochemie
Obor OECD	Biochemistry and molecular biology
CEP	GA20-00317S GA ČR - Grantová agentura ČR
Výzkumná infrastruktura	e-INFRA CZ - 90140 - CESNET, zájmové sdružení právnických osob
Způsob publikování	Open access
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000707017600029
EID SCOPUS	85116942068
DOI	10.1016/j.celrep.2021.109833
Anotace	Glucose tolerance represents a complex phenotype in which many tissues play important roles and interact to regulate metabolic homeostasis. Here, we perform an analysis of 13C6-glucose tissue distribution, which maps the metabolome and lipidome across 12 metabolically relevant mouse organs and plasma, with integrated 13C6-glucose-derived carbon tracing during oral glucose tolerance test (OGTT). We measure time profiles of water-soluble metabolites and lipids and integrate the global metabolite response into metabolic pathways. During the OGTT, glucose use is turned on with specific kinetics at the organ level, but fasting substrates like β-hydroxybutyrate are switched off in all organs simultaneously. Timeline profiling of 13C-labeled fatty acids and triacylglycerols across tissues suggests that brown adipose tissue may contribute to the circulating fatty acid pool at maximal plasma glucose levels. The GTTAtlas interactive web application serves as a unique resource for the exploration of whole-body glucose metabolism and time profiles of tissue and plasma metabolites during the OGTT.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2022
Elektronická adresa	https://doi.org/10.1016/j.celrep.2021.109833

Počet záznamů: 1