Počet záznamů: 1
Biomarkers of Oxidative Stress and Inflammation in Researches Exposed to Nanoparticles by Inhalation During the Handling of Nanocomposites.
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SYSNO ASEP 0547257 Druh ASEP C - Konferenční příspěvek (mezinárodní konf.) Zařazení RIV D - Článek ve sborníku Název Biomarkers of Oxidative Stress and Inflammation in Researches Exposed to Nanoparticles by Inhalation During the Handling of Nanocomposites. Tvůrce(i) Pelclová, D. (CZ)
Ždímal, Vladimír (UCHP-M) RID, ORCID, SAI
Schwarz, Jaroslav (UCHP-M) RID, ORCID, SAI
Komarc, M. (CZ)
Vlčková, Š. (CZ)
Fenclová, Z. (CZ)
Lischková, L. (CZ)
Dvořáčková, Š. (CZ)
Rössnerová, Andrea (UEM-P) RID
Rössner ml., Pavel (UEM-P) RID, ORCIDZdroj.dok. NANOCON 2018 - Conference Proceedings. - Ostrava : Tanger Ltd., 2019 - ISBN 978-80-87294-89-5 Rozsah stran s. 531-536 Poč.str. 6 s. Forma vydání Tištěná - P Akce Anniversary International Conference on Nanomaterials - Research and Application /10./ Datum konání 17.10.2018 - 19.10.2018 Místo konání Brno Země CZ - Česká republika Typ akce EUR Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova Nanocomposites ; exhaled breath condensate ; oxidative stress Vědní obor RIV DN - Vliv životního prostředí na zdraví Obor OECD Public and environmental health Vědní obor RIV – spolupráce Ústav experimentální medicíny - Vliv životního prostředí na zdraví Institucionální podpora UCHP-M - RVO:67985858 ; UEM-P - RVO:68378041 UT WOS 000513131900092 EID SCOPUS 85062955844 Anotace At present, little is known about the health effects in the workers processing nanocomposites. In our study, 20 researchers (41.8 +/- 11.4 y/o), handling nanocomposites for 17.8 +/- 10.0 years were examined pre-shift and post-shift, together with 21 controls (42.7 +/- 11.5 y/o). Biomarkers of oxidative stress derived from lipids, nucleic acids, proteins and markers of inflammation were analyzed in the exhaled breath condensate (EBC). Aerosol exposure was monitored during three nanoparticle generation operations: smelting, welding and nanocomposite machining. Mass concentrations during these operations ranged from 0.120 to 1.840 mg/m(3), and median particle number concentrations from 4.8x10(4) to 5.4x10(5) particles/cm(3). Nanoparticles accounted for 40 to 95 % of particles, with Fe and Mn prevailing. Significant elevations were already seen in most oxidative stress markers and in several inflammation markers in the pre-shift samples relative to the controls. Significant associations were found between working in nanocomposite synthesis and the majority of EBC biomarkers. Chronic bronchitis was more frequent in researchers. A minor, but significant post-shift decrease of lung function parameters was found. We conclude that workers in nanocomposite synthesis may be at risk of developing airway disorders with time. From all the markers analyzed in EBC, the following markers were most robust and could be recommended for preventive examinations: 8-hydroxy-2-deoxyguanosine (8-OHdG) and 5-hydroxymethyl uracil (5-OHMeU) from nucleic acids, o-tyrosine (o-Tyr) and 3-nitrotyrosine (3-NOTyr) from proteins, and malondialdehyde and aldehydes C6-C13 from lipids. Among the markers of inflammation, tumor necrosis factor (TNF) and leukotriene B4 appeared to be the most useful. Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2022
Počet záznamů: 1