Počet záznamů: 1
Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art
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SYSNO ASEP 0547183 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art Tvůrce(i) Chaudhary, P. (IE)
Milluzzo, G. (IE)
Ahmed, H. (IE)
Odložilík, Boris (FZU-D) ORCID
McMurray, A. (IE)
Prise, K. M. (IE)
Borghesi, M. (IE)Celkový počet autorů 7 Číslo článku 624963 Zdroj.dok. Frontiers in Physics. - : Frontiers Research Foundation - ISSN 2296-424X
Roč. 9, Apr (2021)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova protontherapy ; cancer ; radiobiology ; laser-driven ions ; particle accelerator ; ultra-high dose rate Vědní obor RIV BL - Fyzika plazmatu a výboje v plynech Obor OECD Fluids and plasma physics (including surface physics) Výzkumná infrastruktura ELI Beamlines III - 90141 - Fyzikální ústav AV ČR, v. v. i. Způsob publikování Open access Institucionální podpora FZU-D - RVO:68378271 UT WOS 000642239200001 EID SCOPUS 85104594063 DOI 10.3389/fphy.2021.624963 Anotace The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index. Recent studies show that normal tissue sparing can be further enhanced through proton delivery at 100 Gy/s and above, in the so-called FLASH regime. This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. An extensive investigation of the radiobiology of laser-driven protons is therefore not only necessary for future clinical application, but also offers the opportunity of accessing yet untested regimes of radiobiology. Pracoviště Fyzikální ústav Kontakt Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Rok sběru 2022 Elektronická adresa http://hdl.handle.net/11104/0323523
Počet záznamů: 1