Počet záznamů: 1  

Molecular Mechanisms of Mast Cell Activation by Cholesterol-Dependent Cytolysins

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    SYSNO ASEP0544808
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevMolecular Mechanisms of Mast Cell Activation by Cholesterol-Dependent Cytolysins
    Tvůrce(i) Dráberová, Lubica (UMG-J) RID
    Tůmová, Magda (UMG-J)
    Dráber, Petr (UMG-J) RID
    Celkový počet autorů3
    Číslo článku670205
    Zdroj.dok.Frontiers in Immunology - ISSN 1664-3224
    Roč. 12, June (2021)
    Poč.str.15 s.
    Forma vydáníOnline - E
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovamast cell ; cholesterol-dependent cytolysins ; pore-forming toxins ; Ca2+ signaling ; cytokine production ; streptolysin O ; pneumolysin ; listeriolysin O
    Vědní obor RIVEB - Genetika a molekulární biologie
    Obor OECDImmunology
    CEPGA18-18521S GA ČR - Grantová agentura ČR
    GA20-16481S GA ČR - Grantová agentura ČR
    Způsob publikováníOpen access
    Institucionální podporaUMG-J - RVO:68378050
    UT WOS000670070600001
    DOI10.3389/fimmu.2021.670205
    AnotaceMast cells are potent immune sensors of the tissue microenvironment. Within seconds of activation, they release various preformed biologically active products and initiate the process of de novo synthesis of cytokines, chemokines, and other inflammatory mediators. This process is regulated at multiple levels. Besides the extensively studied IgE and IgG receptors, toll-like receptors, MRGPR, and other protein receptor signaling pathways, there is a critical activation pathway based on cholesterol-dependent, pore-forming cytolytic exotoxins produced by Gram-positive bacterial pathogens. This pathway is initiated by binding the exotoxins to the cholesterol-rich membrane, followed by their dimerization, multimerization, pre-pore formation, and pore formation. At low sublytic concentrations, the exotoxins induce mast cell activation, including degranulation, intracellular calcium concentration changes, and transcriptional activation, resulting in production of cytokines and other inflammatory mediators. Higher toxin concentrations lead to cell death. Similar activation events are observed when mast cells are exposed to sublytic concentrations of saponins or some other compounds interfering with the membrane integrity. We review the molecular mechanisms of mast cell activation by pore-forming bacterial exotoxins, and other compounds inducing cholesterol-dependent plasma membrane perturbations. We discuss the importance of these signaling pathways in innate and acquired immunity.
    PracovištěÚstav molekulární genetiky
    KontaktGabriela Marešová, maresova@img.cas.cz, Tel.: 241 063 217
    Rok sběru2022
    Elektronická adresahttps://www.frontiersin.org/articles/10.3389/fimmu.2021.670205/full
Počet záznamů: 1