Počet záznamů: 1
Molecular Mechanisms of Mast Cell Activation by Cholesterol-Dependent Cytolysins
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SYSNO ASEP 0544808 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Molecular Mechanisms of Mast Cell Activation by Cholesterol-Dependent Cytolysins Tvůrce(i) Dráberová, Lubica (UMG-J) RID
Tůmová, Magda (UMG-J)
Dráber, Petr (UMG-J) RIDCelkový počet autorů 3 Číslo článku 670205 Zdroj.dok. Frontiers in Immunology. - : Frontiers Media - ISSN 1664-3224
Roč. 12, June (2021)Poč.str. 15 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova mast cell ; cholesterol-dependent cytolysins ; pore-forming toxins ; Ca2+ signaling ; cytokine production ; streptolysin O ; pneumolysin ; listeriolysin O Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Immunology CEP GA18-18521S GA ČR - Grantová agentura ČR GA20-16481S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UMG-J - RVO:68378050 UT WOS 000670070600001 DOI 10.3389/fimmu.2021.670205 Anotace Mast cells are potent immune sensors of the tissue microenvironment. Within seconds of activation, they release various preformed biologically active products and initiate the process of de novo synthesis of cytokines, chemokines, and other inflammatory mediators. This process is regulated at multiple levels. Besides the extensively studied IgE and IgG receptors, toll-like receptors, MRGPR, and other protein receptor signaling pathways, there is a critical activation pathway based on cholesterol-dependent, pore-forming cytolytic exotoxins produced by Gram-positive bacterial pathogens. This pathway is initiated by binding the exotoxins to the cholesterol-rich membrane, followed by their dimerization, multimerization, pre-pore formation, and pore formation. At low sublytic concentrations, the exotoxins induce mast cell activation, including degranulation, intracellular calcium concentration changes, and transcriptional activation, resulting in production of cytokines and other inflammatory mediators. Higher toxin concentrations lead to cell death. Similar activation events are observed when mast cells are exposed to sublytic concentrations of saponins or some other compounds interfering with the membrane integrity. We review the molecular mechanisms of mast cell activation by pore-forming bacterial exotoxins, and other compounds inducing cholesterol-dependent plasma membrane perturbations. We discuss the importance of these signaling pathways in innate and acquired immunity. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2022 Elektronická adresa https://www.frontiersin.org/articles/10.3389/fimmu.2021.670205/full
Počet záznamů: 1