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Minireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions
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SYSNO ASEP 0544568 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Minireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions Tvůrce(i) Valeš, Karel (FGU-C) RID, ORCID, SAI
Holubová, K. (CZ)Číslo článku 136098 Zdroj.dok. Neuroscience Letters. - : Elsevier - ISSN 0304-3940
Roč. 761, Sep 14 (2021)Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. IE - Irsko Klíč. slova schizophrenia ; antipsychotics ; cognition ; Morris water maze ; pre-pulse inhibition ; MK-801 Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP EF16_025/0007444 GA MZd - Ministerstvo zdravotnictví GA18-09296S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000672856300001 EID SCOPUS 85110107795 DOI 10.1016/j.neulet.2021.136098 Anotace Schizophrenia is a debilitating mental disorder characterized by positive, negative and cognitive symptoms. Whereas positive symptoms are satisfactorily addressed by current antipsychotic treatment, negative and cognitive symptomatic treatment remains largely ineffective. This review investigates the treatment efficacy regarding cognitive symptoms and evaluates the contribution of different monoamine receptor systems involved in schizophrenia pathophysiology to cognition. In the review, we included preclinical studies assessing the effect of different treatments on cognition in pre-pulse inhibition and two spatial cognitive tests. While pre-pulse inhibition investigates pre-attentive processes operating outside of conscious awareness, the spatial tasks require continuous attention and active engagement in task solving for a successful outcome. The schizophrenia-like phenotype was attained by acute or subchronic administration of non-competitive NMDA receptor antagonist MK-801. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2022 Elektronická adresa https://doi.org/10.1016/j.neulet.2021.136098
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