Počet záznamů: 1  

Minireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions

  1. 1.
    SYSNO ASEP0544568
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevMinireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions
    Tvůrce(i) Valeš, Karel (FGU-C) RID, ORCID
    Holubová, K. (CZ)
    Číslo článku136098
    Zdroj.dok.Neuroscience Letters. - : Elsevier - ISSN 0304-3940
    Roč. 761, Sep 14 (2021)
    Poč.str.7 s.
    Jazyk dok.eng - angličtina
    Země vyd.IE - Irsko
    Klíč. slovaschizophrenia ; antipsychotics ; cognition ; Morris water maze ; pre-pulse inhibition ; MK-801
    Vědní obor RIVFH - Neurologie, neurochirurgie, neurovědy
    Obor OECDNeurosciences (including psychophysiology
    CEPEF16_025/0007444 GA MZd - Ministerstvo zdravotnictví
    GA18-09296S GA ČR - Grantová agentura ČR
    Způsob publikováníOmezený přístup
    Institucionální podporaFGU-C - RVO:67985823
    UT WOS000672856300001
    EID SCOPUS85110107795
    DOI10.1016/j.neulet.2021.136098
    AnotaceSchizophrenia is a debilitating mental disorder characterized by positive, negative and cognitive symptoms. Whereas positive symptoms are satisfactorily addressed by current antipsychotic treatment, negative and cognitive symptomatic treatment remains largely ineffective. This review investigates the treatment efficacy regarding cognitive symptoms and evaluates the contribution of different monoamine receptor systems involved in schizophrenia pathophysiology to cognition. In the review, we included preclinical studies assessing the effect of different treatments on cognition in pre-pulse inhibition and two spatial cognitive tests. While pre-pulse inhibition investigates pre-attentive processes operating outside of conscious awareness, the spatial tasks require continuous attention and active engagement in task solving for a successful outcome. The schizophrenia-like phenotype was attained by acute or subchronic administration of non-competitive NMDA receptor antagonist MK-801.
    PracovištěFyziologický ústav
    KontaktLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Rok sběru2022
    Elektronická adresahttps://doi.org/10.1016/j.neulet.2021.136098
Počet záznamů: 1