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The abnormalities of adrenomedullary hormonal system in genetic hypertension: their contribution to altered regulation of blood pressure
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SYSNO ASEP 0544562 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The abnormalities of adrenomedullary hormonal system in genetic hypertension: their contribution to altered regulation of blood pressure Tvůrce(i) Vavřínová, Anna (FGU-C) RID, ORCID, SAI
Behuliak, Michal (FGU-C) RID, ORCID
Vaněčková, Ivana (FGU-C) RID, ORCID
Zicha, Josef (FGU-C) RID, ORCID, SAIZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 70, č. 3 (2021), s. 307-326Poč.str. 20 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova adrenal gland ; chromaffin cells ; epinephrine ; blood pressure ; cardiovascular system ; stress Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP GJ16-10349Y GA ČR - Grantová agentura ČR GC19-08260J GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000675528500002 EID SCOPUS 85112124536 DOI 10.33549/physiolres.934687 Anotace It is widely accepted that sympathetic nervous system plays a crucial role in the development of hypertension. On the other hand, the role of adrenal medulla (the adrenomedullary component of the sympathoadrenal system) in the development and maintenance of high blood pressure in man as well as in experimental models of hypertension is still controversial. Spontaneously hypertensive rats (SHR) are the most widely used animal model of human essential hypertension characterized by sympathetic hyperactivity. However, the persistence of moderately elevated blood pressure in SHR subjected to sympathectomy neonatally as well as the resistance of adult SHR to the treatment by sympatholytic drugs suggests that other factors (including enhanced activity of the adrenomedullary hormonal system) are involved in the pathogenesis of hypertension of SHR. This review describes abnormalities in adrenomedullary hormonal system of SHR rats starting with the hyperactivity of brain centers regulating sympathetic outflow, through the exaggerated activation of sympathoadrenal preganglionic neurons, to the local changes in chromaffin cells of adrenal medulla. All the above alterations might contribute to the enhanced release of epinephrine and/or norepinephrine from adrenal medulla. Special attention is paid to the alterations in the expression of genes involved in catecholamine biosynthesis, storage, release, reuptake, degradation and adrenergic receptors in chromaffin cells of SHR. The contribution of the adrenomedullary hormonal system to the development and maintenance of hypertension as well as its importance during stressful conditions is also discussed. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2022 Elektronická adresa https://www.biomed.cas.cz/physiolres/pdf/2021/70_307.pdf
Počet záznamů: 1