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p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
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SYSNO ASEP 0543951 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice Tvůrce(i) Bora, P. (CZ)
Gahurová, Lenka (UZFG-Y) ORCID
Mašek, T. (CZ)
Hauserová, A. (CZ)
Potěšil, D. (CZ)
Jansová, Denisa (UZFG-Y) ORCID
Šušor, Andrej (UZFG-Y) RID, ORCID
Zdráhal, Z. (CZ)
Ajduk, A. (CZ)
Pospíšek, M. (CZ)
Bruce, A. W. (CZ)Číslo článku 788 Zdroj.dok. Communications Biology. - : Nature Publishing Group
Roč. 4, č. 1 (2021)Poč.str. 19 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova early blastocyst development ; mouse Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Developmental biology Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000668739100001 EID SCOPUS 85111784798 DOI 10.1038/s42003-021-02290-z Anotace Successful specification of the two mouse blastocyst inner cell mass (ICM) lineages (the primitive endoderm (PrE) and epiblast) is a prerequisite for continued development and requires active fibroblast growth factor 4 (FGF4) signaling. Previously, we identified a role for p38 mitogen-activated protein kinases (p38-MAPKs) during PrE differentiation, but the underlying mechanisms have remained unresolved. Here, we report an early blastocyst window of p38-MAPK activity that is required to regulate ribosome-related gene expression, rRNA precursor processing, polysome formation and protein translation. We show that p38-MAPK inhibition-induced PrE phenotypes can be partially rescued by activating the translational regulator mTOR. However, similar PrE phenotypes associated with extracellular signal-regulated kinase (ERK) pathway inhibition targeting active FGF4 signaling are not affected by mTOR activation. These data indicate a specific role for p38-MAPKs in providing a permissive translational environment during mouse blastocyst PrE differentiation that is distinct from classically reported FGF4-based mechanisms. Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a permissive translational environment during mouse blastocyst primitive endoderm differentiation. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2022 Elektronická adresa https://www.nature.com/articles/s42003-021-02290-z
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