Počet záznamů: 1

Ictal Gamma-Band Interactions Localize Ictogenic Nodes of the Epileptic Network in Focal Cortical Dysplasia

SYSNO ASEP	0543462
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Ictal Gamma-Band Interactions Localize Ictogenic Nodes of the Epileptic Network in Focal Cortical Dysplasia
Tvůrce(i)	Janča, R. (CZ) Jahodová, A. (CZ) Hlinka, Jaroslav (UIVT-O)_{RID, SAI, ORCID} Ježdík, P. (CZ) Svobodová, L. (CZ) Kudr, M. (CZ) Kalina, A. (CZ) Marusič, P. (CZ) Kršek, P. (CZ) Jiruška, Přemysl (FGU-C)_{RID, ORCID, SAI}
Celkový počet autorů	10
Zdroj.dok.	Clinical Neurophysiology. - : Elsevier - ISSN 1388-2457 Roč. 132, č. 8 (2021), s. 1927-1936
Poč.str.	10 s.
Forma vydání	Tištěná - P
Jazyk dok.	eng - angličtina
Země vyd.	IE - Irsko
Klíč. slova	Epilepsy ; Effective connectivity ; Intracranial EEG ; Networks ; Seizure onset zone ; Outcome
Vědní obor RIV	FH - Neurologie, neurochirurgie, neurovědy
Obor OECD	Neurosciences (including psychophysiology
Vědní obor RIV – spolupráce	Fyziologický ústav - Neurologie, neurochirurgie, neurovědy
CEP	NV17-28427A GA MZd - Ministerstvo zdravotnictví
Způsob publikování	Omezený přístup
Institucionální podpora	UIVT-O - RVO:67985807 ; FGU-C - RVO:67985823
UT WOS	000674175200021
EID SCOPUS	85109523613
DOI	10.1016/j.clinph.2021.04.016
Anotace	Objective: Epilepsy surgery fails in > 30% of patients with focal cortical dysplasia (FCD). The seizure persistence after surgery can be attributed to the inability to precisely localize the tissue with an endogenous potential to generate seizures. In this study, we aimed to identify the critical components of the epileptic network that were actively involved in seizure genesis. Methods: The directed transfer function was applied to intracranial EEG recordings and the effective connectivity was determined with a high temporal and frequency resolution. Pre-ictal network properties were compared with ictal epochs to identify regions actively generating ictal activity and discriminate them from the areas of propagation. Results: Analysis of 276 seizures from 30 patients revealed the existence of a seizure-related network reconfiguration in the gamma-band (25–170 Hz, p < 0.005) – ictogenic nodes. Unlike seizure onset zone, resecting the majority of ictogenic nodes correlated with favorable outcomes (p < 0.012). Conclusion: The prerequisite to successful epilepsy surgery is the accurate identification of brain areas from which seizures arise. We show that in FCD-related epilepsy, gamma-band network markers can reliably identify and distinguish ictogenic areas in macroelectrode recordings, improve intracranial EEG interpretation and better delineate the epileptogenic zone. Significance: Ictogenic nodes localize the critical parts of the epileptogenic tissue and increase the diagnostic yield of intracranial evaluation.
Pracoviště	Ústav informatiky
Kontakt	Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800
Rok sběru	2022
Elektronická adresa	http://dx.doi.org/10.1016/j.clinph.2021.04.016

Počet záznamů: 1