Počet záznamů: 1
Fabrication of a glycerol-citrate polymer coated tricalcium phosphate bone cements: structural investigation and material properties
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SYSNO ASEP 0543306 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Fabrication of a glycerol-citrate polymer coated tricalcium phosphate bone cements: structural investigation and material properties Tvůrce(i) Sopčák, T. (SK)
Medvecký, L. (SK)
Giretová, M. (SK)
Stulajterova, R. (SK)
Brus, Jiří (UMCH-V) RID, ORCID
Urbanová, Martina (UMCH-V) RID, ORCID
Kromka, F. (SK)
Podobová, M. (SK)
Fáberová, M. (SK)Číslo článku 231 Zdroj.dok. Journal of Polymer Research. - : Springer - ISSN 1022-9760
Roč. 28, č. 6 (2021)Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. TW - Taiwan - Čína Klíč. slova glycerol-citrate ; tricalcium phosphate ; elastomers Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000756714700004 EID SCOPUS 85107376953 DOI 10.1007/s10965-021-02596-w Anotace Calcium phosphate cements (CPCs) belong to one of the most prominent biomaterials used for filling and regeneration of hard tissues, however poor mechanical and biological properties limit their widespread use in some clinical applications. To solve these problems, a biodegradable glycerol-citrate (G-CA) polyester was synthesized and coated on tricalcium phosphate cement (TCP) powders in amounts up to 10 wt% of the G-CA content using a simple solution infiltration technique in ethanol solution. Chemical and structural analysis of the G-CA elastomer and TCP/G-CA composites were thoroughly analyzed with chromatographic techniques, solid-state nuclear magnetic resonance (ssNMR), differential scanning calorimetry and thermogravimetry (DSC/TG), X-ray diffraction (XRD), Fourier-Transform Infrared spectroscopy (FTIR) and field emission scanning electron microscopy (SEM). The results demonstrated that the incorporation of 2.5 and 5 wt% of G-CA into TCP cement led to a significant increase of mechanical strength of the cements due to the formation of thin and homogeneous elastomer coating on cement particles, reinforcing the microstructure through hydrogen bonds between residual COOH groups of polymer and surface phosphate groups of the cement matrix. Additional in vitro testing of extracts cytotoxicity revealed a high proliferation of osteoblasts in all composites, demonstrating a promising application potential in regenerative medicine. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://link.springer.com/article/10.1007%2Fs10965-021-02596-w
Počet záznamů: 1