Počet záznamů: 1
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
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SYSNO ASEP 0543092 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network Tvůrce(i) Vinarov, Z. (BE)
Abrahamsson, B. (SE)
Artursson, P. (SE)
Batchelor, H. (GB)
Berben, P. (BE)
Bernkop-Schnurch, A. (AT)
Butler, J. (GB)
Ceulemans, J. (BE)
Davies, N. (SE)
Dupont, D. (FR)
Flaten, G. E. (NO)
Fotaki, N. (GB)
Griffin, B. T. (IE)
Jannin, V. (FR)
Keemink, J. (BE)
Kesisoglou, F. (US)
Koziolek, M. (DE)
Kuentz, M. (CH)
Mackie, A. (GB)
Melendez-Martinez, A. J. (ES)
McAllister, M. (GB)
Mullertz, A. (DK)
O'Driscoll, C. M. (IE)
Parrott, N. (CH)
Paszkowska, J. (PL)
Pávek, P. (CZ)
Porter, C. J. H. (AU)
Reppas, C. (GR)
Stillhart, C. (CH)
Sugano, K. (JP)
Toader, E. (RO)
Valentová, Kateřina (MBU-M) RID, ORCID
Vertzoni, M. (GR)
De Wildt, S. N. (NL)
Wilson, C. G. (GB)
Augustijns, P. (BE)Zdroj.dok. Advanced Drug Delivery Reviews. - : ELSEVIER SCIENCE BV - ISSN 0169-409X
Roč. 171, APR 2021 (2021), s. 289-331Poč.str. 43 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Specific patient populations ; Regional differences ; Advanced formulations ; Amorphous solid dispersions ; Lipid-based formulations ; Food-drug interactions ; Microbiome ; In vitro tools ; PBPK modeling Vědní obor RIV FR - Farmakologie a lékárnická chemie Obor OECD Pharmacology and pharmacy CEP LTC19039 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LTC18003 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA18-00132S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000651730200017 EID SCOPUS 85101727356 DOI 10.1016/j.addr.2021.02.001 Anotace Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2022 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0169409X21000351?via%3Dihub
Počet záznamů: 1