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Magnetic superporous poly(2-hydroxyethyl methacrylate) hydrogel scaffolds for bone tissue engineering
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SYSNO ASEP 0542997 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Magnetic superporous poly(2-hydroxyethyl methacrylate) hydrogel scaffolds for bone tissue engineering Tvůrce(i) Zasońska, Beata Anna (UMCH-V) RID, ORCID
Brož, Antonín (FGU-C) RID, ORCID, SAI
Šlouf, Miroslav (UMCH-V) RID, ORCID
Hodan, Jiří (UMCH-V)
Petrovský, Eduard (GFU-E) ORCID, RID
Hlídková, Helena (UMCH-V) RID, ORCID
Horák, Daniel (UMCH-V) RID, ORCIDČíslo článku 1871 Zdroj.dok. Polymers. - : MDPI
Roč. 13, č. 11 (2021)Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova poly(2-hydroxyethyl methacrylate) ; superporous ; scaffold Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Vědní obor RIV – spolupráce Fyziologický ústav - Biotechnologie a bionika
Geofyzikální ústav - Zemský magnetismus, geodézie, geografieCEP GA20-07015S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 ; FGU-C - RVO:67985823 ; GFU-E - RVO:67985530 UT WOS 000660535800001 EID SCOPUS 85108223800 DOI 10.3390/polym13111871 Anotace Magnetic maghemite (γ-Fe2O3) nanoparticles obtained by a coprecipitation of iron chlorides were dispersed in superporous poly(2-hydroxyethyl methacrylate) scaffolds containing continuous pores prepared by the polymerization of 2-hydroxyethyl methacrylate (HEMA) and ethylene dimethacrylate (EDMA) in the presence of ammonium oxalate porogen. The scaffolds were thoroughly characterized by scanning electron microscopy (SEM), vibrating sample magnetometry, FTIR spectroscopy, and mechanical testing in terms of chemical composition, magnetization, and mechanical properties. While the SEM microscopy confirmed that the hydrogels contained communicating pores with a length of ≤2 mm and thickness of ≤400 μm, the SEM/EDX microanalysis documented the presence of γ-Fe2O3 nanoparticles in the polymer matrix. The saturation magnetization of the magnetic hydrogel reached 2.04 Am2/kg, which corresponded to 3.7 wt.% of maghemite in the scaffold. The shape of the hysteresis loop and coercivity parameters suggested the superparamagnetic nature of the hydrogel. The highest toughness and compressive modulus were observed with γ-Fe2O3-loaded PHEMA hydrogels. Finally, the cell seeding experiments with the human SAOS-2 cell line showed a rather mediocre cell colonization on the PHEMA-based hydrogel scaffolds. However, the incorporation of γ-Fe2O3 nanoparticles into the hydrogel improved the cell adhesion significantly. This could make this composite a promising material for bone tissue engineering. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/2073-4360/13/11/1871
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