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Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy
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SYSNO ASEP 0542465 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy Tvůrce(i) Breinlinger, S. (DE)
Phillips, T. J. (US)
Haram, B. N. (US)
Mareš, Jan (MBU-M) ORCID
Yerena, J. A. M. (CZ)
Hrouzek, Pavel (MBU-M) ORCID
Sobotka, Roman (MBU-M) RID, ORCID
Henderson, W. M. (US)
Schmieder, P. (DE)
Williams, S. M. (US)
Lauderdale, J. D. (US)
Wilde, H. D. (US)
Gerrin, W. (US)
Kust, A. (CZ)
Washington, J. W. (US)
Wagner, C. (DE)
Geier, B. (DE)
Liebeke, M. (DE)
Enke, H. (DE)
Niedermeyer, T. H. J. (DE)
Wilde, S. B. (US)Číslo článku 1335 Zdroj.dok. Science. - : American Association for the Advancement of Science - ISSN 0036-8075
Roč. 371, č. 6536 (2021)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova eagle ; cyanobacterial neurotoxin ; vacuolar myelinopathy Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP GC19-21649J GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000636043400031 EID SCOPUS 85103521011 DOI 10.1126/science.aax9050 Anotace Vacuolar myelinopathy is a fatal neurological disease that was initially discovered during a mysterious mass mortality of bald eagles in Arkansas in the United States. The cause of this wildlife disease has eluded scientists for decades while its occurrence has continued to spread throughout freshwater reservoirs in the southeastern United States. Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species Aetokthonos hydrillicola growing on aquatic vegetation, primarily the invasive Hydrilla verticillata. Here, we describe the identification, biosynthetic gene cluster, and biological activity of aetokthonotoxin, a pentabrominated biindole alkaloid that is produced by the cyanobacterium A. hydrillicola. We identify this cyanobacterial neurotoxin as the causal agent of vacuolar myelinopathy and discuss environmental factors-especially bromide availability-that promote toxin production. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2022 Elektronická adresa https://science.sciencemag.org/content/371/6536/eaax9050.abstract
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