Počet záznamů: 1
Quadruplex-Forming Motif Inserted into 3 ' UTR of Ty1his3-AI Retrotransposon Inhibits Retrotransposition in Yeast
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SYSNO ASEP 0542265 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Quadruplex-Forming Motif Inserted into 3 ' UTR of Ty1his3-AI Retrotransposon Inhibits Retrotransposition in Yeast Tvůrce(i) Tokan, Viktor (BFU-R) ORCID
Lorenzo, Jose Luis Rodriguez (BFU-R)
Jedlička, Pavel (BFU-R) ORCID
Kejnovská, Iva (BFU-R) RID, ORCID
Hobza, Roman (BFU-R) RID, ORCID
Kejnovský, Eduard (BFU-R) RID, ORCIDCelkový počet autorů 6 Číslo článku 347 Zdroj.dok. Biology. - : MDPI
Roč. 10, č. 4 (2021)Poč.str. 13 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova Ty1 LTR retrotransposon ; G-quadruplex ; retrotransposition ; N-methyl mesoporphyrin (NMM) ; Pif1 helicase ; yeast Vědní obor RIV BO - Biofyzika Obor OECD Other biological topics CEP GA18-00258S GA ČR - Grantová agentura ČR GA21-00580S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora BFU-R - RVO:68081707 UT WOS 000642722900001 DOI 10.3390/biology10040347 Anotace Current multiagent chemotherapy regimens have improved the cure rate in acute leukemia patients, but they are highly toxic and poorly efficient in relapsed patients. To improve the treatment approaches, new specific molecules are needed. The G-quadruplexes (G4s), which are noncanonical nucleic acid structures found in specific guanine-rich DNA or RNA, are involved in many cellular events, including control of gene expression. G4s are considered as targets for the development of anticancer agents. Heterocyclic molecules are well known to target and stabilize G4 structures. Thus, a new series of 2,9-bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline derivatives (1a-i) was designed, synthesized, and evaluated against five human myeloid leukemia cell lines (K562, KU812, MV4-11, HL60, and U937). Their ability to stabilize various oncogene promoter G4 structures (c-MYC, BCL-2, and K-RAS) as well as the telomeric G4 was also determined through the fluorescence resonance energy transfer melting assay and native mass spectrometry. In addition, the more bioactive ligands 1g-i were tested for telomerase activity in HuT78 and MV4-11 protein extracts. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/2079-7737/10/4/347
Počet záznamů: 1