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Reversible multilayered vesicle-like structures with fluid hydrophobic and interpolyelectrolyte layers
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SYSNO ASEP 0542110 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Reversible multilayered vesicle-like structures with fluid hydrophobic and interpolyelectrolyte layers Tvůrce(i) Murmiliuk, A. (CZ)
Filippov, S. K. (FI)
Rud, O. (CZ)
Košovan, P. (CZ)
Tošner, Z. (CZ)
Radulescu, A. (DE)
Skandalis, A. (GR)
Pispas, S. (GR)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Štěpánek, M. (CZ)Zdroj.dok. Journal of Colloid and Interface Science. - : Elsevier - ISSN 0021-9797
Roč. 599, October (2021), s. 313-325Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova electrostatic coassembly ; block polyelectrolytes ; core/shell particles Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry CEP GA19-10429S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000659386600005 EID SCOPUS 85105115935 DOI 10.1016/j.jcis.2021.04.050 Anotace Hydrophobic blocks of amphiphilic block copolymers often form glassy micellar cores at room temperature with a rigid structure that limits their applications as nanocapsules for targeted delivery. Nevertheless, we prepared and analyzed core/shell micelles with a soft core, formed by a self-assembled block copolymer consisting of a hydrophobic block and a polycation block, poly(lauryl acrylate)-block-poly(trimethyl-aminoethyl acrylate) (PLA-QPDMAEA), in aqueous solution. By light and small-angle neutron scattering, by transmission electron microscopy and by fluorescence spectroscopy, we showed that these core/shell micelles are spherical and cylindrical with a fluid-like PLA core and a positively charged outer shell and that they can encapsulate and release hydrophobic solutes. Moreover, after mixing these PLA-QPDMAEA core/shell micelles with another diblock copolymer, consisting of a hydrophilic block and a polyanion block, namely poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-PMAA), we observed the formation of novel vesicle-like multicompartment structures containing both soft hydrophobic and interpolyelectrolyte (IPEC) layers. By combining small-angle neutron scattering with self-consistent field modeling, we confirmed the formation of these complex vesicle-like structures with a swollen PEO core, an IPEC inner layer, a PLA soft layer, an IPEC outer layer and a loose PEO corona. Thus, these multicompartment micelles with fluid and IPEC layers and a hydrophilic corona may be used as nanocapsules with several tunable properties, including the ability to control the thickness of each layer, the charge of the IPEC layers and the stability of the micelles, to deliver both hydrophobic and multivalent solutes. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S002197972100552X
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