Počet záznamů: 1

Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults

SYSNO ASEP	0541688
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults
Tvůrce(i)	Ošťádal, Bohuslav (FGU-C)_{RID, ORCID} Ošťádalová, Ivana (FGU-C)_RID Szárszoi, O. (CZ) Netuka, I. (CZ) Olejníčková, Veronika (FGU-C)_{RID, ORCID, SAI} Hlaváčková, Markéta (FGU-C)_{RID, ORCID}
Zdroj.dok.	Canadian Journal of Physiology and Pharmacology. - : Canadian Science Publishing - ISSN 0008-4212 Roč. 99, č. 1 (2021), s. 1-8
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	CA - Kanada
Klíč. slova	heart ; perinatal hypoxia ; ischemia/reperfusion injury ; sex differences
Vědní obor RIV	ED - Fyziologie
Obor OECD	Physiology (including cytology)
CEP	GA18-03461S GA ČR - Grantová agentura ČR
	GJ19-04790Y GA ČR - Grantová agentura ČR
Způsob publikování	Open access
Institucionální podpora	FGU-C - RVO:67985823
UT WOS	000613249900001
EID SCOPUS	85099853569
DOI	10.1139/cjpp-2020-0310
Anotace	Epidemiological studies have demonstrated a relationship between the adverse influence of perinatal development and increased risk of ischemic heart disease in adults. From negative factors to which the fetus is subjected, the most important is hypoxia. The fetus may experience hypoxic stress under different conditions, including pregnancy at high altitude, pregnancy with anemia, placental insufficiency, and heart, lung, and kidney disease. One of the most common insults during the early stages of postnatal development is hypoxemia due to congenital cyanotic heart defects. Experimental studies have demonstrated a link between early hypoxia and increased risk of ischemia/reperfusion injury (I/R) in adults. Furthermore, it has been observed that late myocardial effects of chronic hypoxia, experienced in early life, may be sex-dependent. Unlike in males, perinatal hypoxia significantly increased cardiac tolerance to acute I/R injury in adult females, expressed as decreased infarct size and lower incidence of ischemic arrhythmias. It was suggested that early hypoxia may result in sex-dependent programming of specific genes in the offspring with the consequence of increased cardiac susceptibility to I/R injury in adult males. These results would have important clinical implications, since cardiac sensitivity to oxygen deprivation in adult patients may be significantly influenced by perinatal hypoxia in a sex-dependent manner.
Pracoviště	Fyziologický ústav
Kontakt	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Rok sběru	2022
Elektronická adresa	https://doi.org/10.1139/cjpp-2020-0310

Počet záznamů: 1