Počet záznamů: 1

pH-responsive polymersome-mediated delivery of doxorubicin into tumor sites enhances the therapeutic efficacy and reduces cardiotoxic effects

SYSNO ASEP	0541439
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	pH-responsive polymersome-mediated delivery of doxorubicin into tumor sites enhances the therapeutic efficacy and reduces cardiotoxic effects
Tvůrce(i)	Calumby Albuquerque, Lindomar J. (UMCH-V) Sincari, Vladimir (UMCH-V)_{ORCID, RID} Jäger, Alessandro (UMCH-V)_{RID, ORCID} Kučka, Jan (UMCH-V)_{RID, ORCID} Humajová, J. (CZ) Pankrác, J. (CZ) Páral, P. (CZ) Heizer, T. (CZ) Janoušková, Olga (UMCH-V)_{RID, SAI, ORCID} Davidovich, I. (IL) Talmon, Y. (IL) Pouckova, P. (CZ) Štěpánek, Petr (UMCH-V)_{RID, ORCID} Šefc, L. (CZ) Hrubý, Martin (UMCH-V)_{RID, ORCID} Giacomelli, F. C. (BR) Jäger, Eliezer (UMCH-V)_{ORCID, RID}
Zdroj.dok.	Journal of Controlled Release. - : Elsevier - ISSN 0168-3659 Roč. 332, 10 April (2021), s. 529-538
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	NL - Nizozemsko
Klíč. slova	nanomedicine ; pH-responsive polymersomes ; doxorubicin
Vědní obor RIV	CD - Makromolekulární chemie
Obor OECD	Polymer science
CEP	GJ20-15077Y GA ČR - Grantová agentura ČR
	GJ20-13946Y GA ČR - Grantová agentura ČR
	LM2018133 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	LO1507 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	LTC19032 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Výzkumná infrastruktura	Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
Způsob publikování	Omezený přístup
Institucionální podpora	UMCH-V - RVO:61389013
UT WOS	000646579700007
EID SCOPUS	85102645269
DOI	10.1016/j.jconrel.2021.03.013
Anotace	The delivery of therapeutics into sites of action by using cargo-delivery platforms potentially minimizes their premature degradation and fast clearance from the bloodstream. Additionally, drug-loaded stimuli-responsive supramolecular assemblies can be produced to respond to the inherent features of tumor microenvironments, such as extracellular acidosis. We report in this framework the use of pH-responsive polymersomes (PSs) manufactured using poly([N-(2-hydroxypropyl)] methacrylamide)35-b-poly[2-(diisopropylamino)ethyl methacrylate]75 as the building unit (PHPMA35-b-PDPA75). The self-assemblies were produced with desired size towards long circulation time and tumor accumulation (hydrodynamic diameter - DH approximately 100 nm), and they could be successfully loaded with 10% w/w DOX (doxorubicin), while maintaining colloidal stability. The DOX loaded amount is presumably mainly burst-released at the acidic microenvironment of tumors thanks to the pH-switchable property of PDPA (pKa approximately 6.8), while reduced drug leakage has been monitored in pH 7.4. Compared to the administration of free DOX, the drug-loaded supramolecular structures greatly enhanced the therapeutic efficacy with effective growth inhibition of EL4 lymphoma tumor model and 100% survival rate in female C57BL/6 black mice over 40 days. The approach also led to reduced cardiotoxic effect. These features highlight the potential application of such nanotechnology-based treatment in a variety of cancer therapies where low local pH is commonly found, and emphasize PHPMA-based nanomedicines as an alternative to PEGylated formulations.
Pracoviště	Ústav makromolekulární chemie
Kontakt	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Rok sběru	2022
Elektronická adresa	https://www.sciencedirect.com/science/article/pii/S0168365921001243?via%3Dihub

Počet záznamů: 1