Počet záznamů: 1
Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice
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SYSNO ASEP 0541390 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Gestational and pubertal exposure to low dose of di-(2-ethylhexyl) phthalate impairs sperm quality in adult mice Tvůrce(i) Dostálová, Pavla (BTO-N)
Žatecká, Eva (BTO-N)
Děd, Lukáš (BTO-N) RID
Elzeinová, Fatima (BTO-N) RID
Valášková, Eliška (BTO-N)
Kubátová, Alena (BTO-N) RID
Korenková, Vlasta (BTO-N) RID
Langerová, Lucie (BTO-N) RID
Komrsková, Kateřina (BTO-N) ORCID
Pěknicová, Jana (BTO-N) RIDCelkový počet autorů 10 Zdroj.dok. Reproductive Toxicology. - : Elsevier - ISSN 0890-6238
Roč. 96, SEP 2020 (2020), s. 175-184Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova DEHP ; Fertility ; Spermatogenesis ; Steroidogenesis Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Reproductive biology (medical aspects to be 3) CEP GA18-11275S GA ČR - Grantová agentura ČR GJ20-17403Y GA ČR - Grantová agentura ČR ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 000582635800019 EID SCOPUS 85087779990 DOI 10.1016/j.reprotox.2020.06.014 Anotace Di-(2-ethylhexyl)-phthalate (DEHP) is a compound widely used as a plasticizer, which can leach from plastics into the environment and thus influence human health. The aim of this study was to analyze whether exposure to an environmentally relevant dose of DEHP during mice fetal development or puberty can cause long-lasting changes detectable month/s after the last exposure. We used a DEHP concentration relevant to a daily human intake of 2.4-3 mu g/kg of body weight/day. CD1 outbred mice were treated either in utero or postnatally during puberty and analyzed in adulthood. Analyzing fertility parameters using morphometric, histologic, genomic and proteomic methods we showed that DEHP exposure leads to decreased sperm concentration and quality, in both experimental groups. Moreover, the changes in anogenital distance, seminal vesicle weight, and testicular gene expression suggest a disturbance of androgen signaling in exposed animals. In conclusion, we hereby present, that the prenatal and pubertal exposure to a low dose of DEHP negatively influenced reproductive endpoints in male mice, and some of the effects were persistent until adulthood. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2021 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0890623820301738?via%3Dihub
Počet záznamů: 1