Počet záznamů: 1
A Three-Arm Parallel-Group Exploratory Trial documents balance improvement without much evidence of white matter integrity changes in people with multiple sclerosis following two months ambulatory neuroproprioceptive “facilitation and inhibition” physical therapy
- 1.
SYSNO ASEP 0540731 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A Three-Arm Parallel-Group Exploratory Trial documents balance improvement without much evidence of white matter integrity changes in people with multiple sclerosis following two months ambulatory neuroproprioceptive “facilitation and inhibition” physical therapy Tvůrce(i) Řasová, K. (CZ)
Bučková, Barbora (UIVT-O) RID, ORCID, SAI
Prokopiusová, T. (CZ)
Procházková, M. (CZ)
Angel, G. (CZ)
Marková, M. (CZ)
Hrušková, N. (CZ)
Štětkářová, I. (CZ)
Špaňhelová, Š. (CZ)
Mareš, J. (CZ)
Tintěra, J. (CZ)
Zach, P. (CZ)
Musil, V. (CZ)
Hlinka, Jaroslav (UIVT-O) RID, SAI, ORCIDZdroj.dok. European Journal of Physical and Rehabilitation Medicine. - : Edizioni Minerva Medica - ISSN 1973-9087
Roč. 57, č. 6 (2021), s. 889-899Poč.str. 34 s. Jazyk dok. eng - angličtina Země vyd. IT - Itálie Klíč. slova adaptive plasticity ; neural plasticity ; multiple sclerosis ; physical therapy ; diffusion tensor imaging ; functional recovery Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology CEP GA13-23940S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UIVT-O - RVO:67985807 UT WOS 000734175600005 EID SCOPUS 85122024185 DOI 10.23736/S1973-9087.21.06701-0 Anotace BACKGROUND: Changes of white matter integrity in people with multiple sclerosis (MS) were documented following mainly motor/skill acquisitions physical therapy, while following neuroproprioceptive ”facilitation, inhibition” (neurofacilitation) only by two pilot studies. Neurofacilitation has potential to induce white matter changes due to possibility to interfere with the neuronal tactility threshold, but stronger evidence is missing. AIM: This study investigates whether neurofacilitation (three physical therapy types) induce white matter changes and if they relate to clinical improvement. DESIGN: The Three-Arm Parallel-Group Exploratory Trial (NCT04355663). SETTING: Each group underwent different kind of two months ambulatory therapy (Motor Program Activating Therapy, Vojta's reflex locomotion, and Functional Electric Stimulation in Posturally Corrected Position). POPULATION: MS people with moderate disability. METHODS: At baseline and after the program, participants underwent magnetic resonance diffusion tensor imaging (DTI) and clinical assessment. Fractional anisotropy maps obtained from DTI were further analyzed using tract-based spatial statistic exploring the mean values in the whole statistic skeleton. Moreover, additional exploratory analysis in 48 regions of white matter was done. RESULTS: 92 people were recruited. DTI data from 61 were analysed. The neurofacilitation (irrespective type of therapy) resulted in significant improvement on the Berg Balance Scale (p=0.0089), mainly driven by the Motor Program Activating Therapy. No statistically significant change in the whole statistic skeleton was observed (only a trend for decrement of fractional anisotropy after Vojta's reflex locomotion). Additional exploratory analysis confirmed significant decrement of fractional anisotropy in the right anterior corona radiata. CONCLUSIONS: Neurofacilitation improved balance without much evidence of white matter integrity changes in people with MS. CLINICAL REHABILITATION IMPACT: The study results point to the importance of neuroproprioceptive “facilitation and inhibition” physical therapy in management of balance in people with multiple sclerosis and the potential to induce white matter changes due to possibility to interfere with the neuronal tactility threshold. Pracoviště Ústav informatiky Kontakt Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Rok sběru 2022 Elektronická adresa http://hdl.handle.net/11104/0318348
Počet záznamů: 1