Počet záznamů: 1
HPMA copolymer-based nanomedicines in controlled drug delivery
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SYSNO ASEP 0539425 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název HPMA copolymer-based nanomedicines in controlled drug delivery Tvůrce(i) Chytil, Petr (UMCH-V) RID, ORCID
Kostka, Libor (UMCH-V) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCIDČíslo článku 115 Zdroj.dok. Journal of Personalized Medicine. - : MDPI
Roč. 11, č. 2 (2021)Poč.str. 22 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova HPMA copolymers ; EPR effect ; drug delivery Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GA20-04790S GA ČR - Grantová agentura ČR GA17-08084S GA ČR - Grantová agentura ČR NU20-08-00255 GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000622736100001 EID SCOPUS 85101223275 DOI 10.3390/jpm11020115 Anotace Recently, numerous polymer materials have been employed as drug carrier systems in medicinal research, and their detailed properties have been thoroughly evaluated. Water-soluble polymer carriers play a significant role between these studied polymer systems as they are advantageously applied as carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, antimicrobial molecules, or multidrug resistance inhibitors. Covalent attachment of carried molecules using a biodegradable spacer is strongly preferred, as such design ensures the controlled release of the drug in the place of a desired pharmacological effect in a reasonable time-dependent manner. Importantly, the synthetic polymer biomaterials based on N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers are recognized drug carriers with unique properties that nominate them among the most serious nanomedicines candidates for human clinical trials. This review focuses on advances in the development of HPMA copolymer-based nanomedicines within the passive and active targeting into the place of desired pharmacological effect, tumors, inflammation or bacterial infection sites. Specifically, this review highlights the safety issues of HPMA polymer-based drug carriers concerning the structure of nanomedicines. The main impact consists of the improvement of targeting ability, especially concerning the enhanced and permeability retention (EPR) effect. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/2075-4426/11/2/115
Počet záznamů: 1