Počet záznamů: 1
Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View
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SYSNO ASEP 0538195 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Improving Stability of Tear Film Lipid Layer via Concerted Action of Two Drug Molecules: A Biophysical View Tvůrce(i) Eftimov, P. (BG)
Olžyńska, Agnieszka (UFCH-W) RID
Melcrová, Adéla (UFCH-W)
Georgiev, G. A. (PT)
Daull, P. (FR)
Garrigue, J.-S. (FR)
Cwiklik, Lukasz (UFCH-W) RID, ORCIDČíslo článku 9490 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 21, č. 24 (2020)Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova dry eye disease ; cationic emulsion ; surface-chemistry ; benzalkonium chloride ; vicious circle ; efficacy ; meibum ; pathophysiology ; moderate ; tension ; tear film Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry CEP GA18-26751S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UFCH-W - RVO:61388955 UT WOS 000602786100001 EID SCOPUS 85097758857 DOI 10.3390/ijms21249490 Anotace The tear film at the ocular surface is covered by a thin layer of lipids. This oily phase stabilizes the film by decreasing its surface tension and improving its viscoelastic properties. Clinically, destabilization and rupture of the tear film are related to dry eye disease and are accompanied by changes in the quality and quantity of tear film lipids. In dry eye, eye drops containing oil-in-water emulsions are used for the supplementation of lipids and surface-active components to the tear film. We explore in detail the biophysical aspects of interactions of specific surface-active compounds, cetalkonium chloride and poloxamer 188, which are present in oil-in-water emulsions, with tear lipids. The aim is to better understand the macroscopically observed eye drops-tear film interactions by rationalizing them at the molecular level. To this end, we employ a multi-scale approach combining experiments on human meibomian lipid extracts, measurements using synthetic lipid films, and in silico molecular dynamics simulations. By combining these methods, we demonstrate that the studied compounds specifically interact with the tear lipid film enhancing its structure, surfactant properties, and elasticity. The observed effects are cooperative and can be further modulated by material packing at the tear-air interface. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2021 Elektronická adresa http://hdl.handle.net/11104/0316017
Počet záznamů: 1