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Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy
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SYSNO ASEP 0535784 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy Tvůrce(i) Dong, L. (AU)
Gopalan, V. (US)
Holland, O. (AU)
Neužil, Jiří (BTO-N) RIDCelkový počet autorů 4 Číslo článku 7941 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 21, č. 21 (2020)Poč.str. 21 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova alpha-tocopheryl succinate ; overcoming drug-resistance ; cervical-cancer cells ; glutamine-metabolism ; mitochondrial targeting Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 000589143400001 EID SCOPUS 85094117459 DOI 10.3390/ijms21217941 Anotace Mitochondria are essential cellular organelles, controlling multiple signalling pathways critical for cell survival and cell death. Increasing evidence suggests that mitochondrial metabolism and functions are indispensable in tumorigenesis and cancer progression, rendering mitochondria and mitochondrial functions as plausible targets for anti-cancer therapeutics. In this review, we summarised the major strategies of selective targeting of mitochondria and their functions to combat cancer, including targeting mitochondrial metabolism, the electron transport chain and tricarboxylic acid cycle, mitochondrial redox signalling pathways, and ROS homeostasis. We highlight that delivering anti-cancer drugs into mitochondria exhibits enormous potential for future cancer therapeutic strategies, with a great advantage of potentially overcoming drug resistance. Mitocans, exemplified by mitochondrially targeted vitamin E succinate and tamoxifen (MitoTam), selectively target cancer cell mitochondria and efficiently kill multiple types of cancer cells by disrupting mitochondrial function, with MitoTam currently undergoing a clinical trial. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2021 Elektronická adresa https://www.mdpi.com/1422-0067/21/21/7941
Počet záznamů: 1