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Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

SYSNO ASEP	0535546
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes
Tvůrce(i)	Kostiv, Uliana (UMCH-V)_RID Kučka, Jan (UMCH-V)_{RID, ORCID} Lobaz, Volodymyr (UMCH-V)_{RID, ORCID} Kotov, Nikolay (UMCH-V)_{RID, ORCID} Janoušková, Olga (UMCH-V)_{RID, SAI, ORCID} Šlouf, Miroslav (UMCH-V)_{RID, ORCID} Krajnik, B. (PL) Podhorodecki, A. (PL) Francová, P. (CZ) Šefc, L. (CZ) Jirák, D. (CZ) Horák, Daniel (UMCH-V)_{RID, ORCID}
Číslo článku	20016
Zdroj.dok.	Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322 Roč. 10, č. 1 (2020), s. 1-14
Poč.str.	14 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	upconversion ; magnetic ; PEG-neridronate
Vědní obor RIV	CD - Makromolekulární chemie
Obor OECD	Polymer science
CEP	GA19-00676S GA ČR - Grantová agentura ČR
	GA18-07983S GA ČR - Grantová agentura ČR
	TE01020118 GA TA ČR - Technologická agentura ČR
	LO1507 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
	8JPL19006 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
Výzkumná infrastruktura	Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
Způsob publikování	Open access
Institucionální podpora	UMCH-V - RVO:61389013
UT WOS	000595719100001
EID SCOPUS	85096206151
DOI	10.1038/s41598-020-77112-z
Anotace	All-in-one multifunctional nanomaterials, which can be visualized simultaneously by several imaging techniques, are required for the efficient diagnosis and treatment of many serious diseases. This report addresses the design and synthesis of upconversion magnetic NaGdF4:Yb3+/Er3+(Tm3+) nanoparticles by an oleic acid-stabilized high-temperature coprecipitation of lanthanide precursors in octadec-1-ene. The nanoparticles, which emit visible or UV light under near-infrared (NIR) irradiation, were modified by in-house synthesized PEG-neridronate to facilitate their dispersibility and colloidal stability in water and bioanalytically relevant phosphate buffered saline (PBS). The cytotoxicity of the nanoparticles was determined using HeLa cells and human fibroblasts (HF). Subsequently, the particles were modified by Bolton-Hunter-neridronate and radiolabeled by 125I to monitor their biodistribution in mice using single-photon emission computed tomography (SPECT). The upconversion and the paramagnetic properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles were evaluated by photoluminescence, magnetic resonance (MR) relaxometry, and magnetic resonance imaging (MRI) with 1 T and 4.7 T preclinical scanners. MRI data were obtained on phantoms with different particle concentrations and during pilot long-time in vivo observations of a mouse model. The biological and physicochemical properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles make them promising as a trimodal optical/MRI/SPECT bioimaging and theranostic nanoprobe for experimental medicine.
Pracoviště	Ústav makromolekulární chemie
Kontakt	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Rok sběru	2021
Elektronická adresa	https://www.nature.com/articles/s41598-020-77112-z

Počet záznamů: 1