Počet záznamů: 1  

Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

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    SYSNO ASEP0535546
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevHighly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes
    Tvůrce(i) Kostiv, Uliana (UMCH-V) RID
    Kučka, Jan (UMCH-V) RID, ORCID
    Lobaz, Volodymyr (UMCH-V) RID, ORCID
    Kotov, Nikolay (UMCH-V) RID, ORCID
    Janoušková, Olga (UMCH-V) RID, SAI, ORCID
    Šlouf, Miroslav (UMCH-V) RID, ORCID
    Krajnik, B. (PL)
    Podhorodecki, A. (PL)
    Francová, P. (CZ)
    Šefc, L. (CZ)
    Jirák, D. (CZ)
    Horák, Daniel (UMCH-V) RID, ORCID
    Číslo článku20016
    Zdroj.dok.Scientific Reports - ISSN 2045-2322
    Roč. 10, č. 1 (2020), s. 1-14
    Poč.str.14 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaupconversion ; magnetic ; PEG-neridronate
    Vědní obor RIVCD - Makromolekulární chemie
    Obor OECDPolymer science
    CEPGA19-00676S GA ČR - Grantová agentura ČR
    GA18-07983S GA ČR - Grantová agentura ČR
    TE01020118 GA TA ČR - Technologická agentura České republiky
    LO1507 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    8JPL19006 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    Výzkumná infrastrukturaCzech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
    Způsob publikováníOpen access
    Institucionální podporaUMCH-V - RVO:61389013
    UT WOS000595719100001
    EID SCOPUS85096206151
    DOI10.1038/s41598-020-77112-z
    AnotaceAll-in-one multifunctional nanomaterials, which can be visualized simultaneously by several imaging techniques, are required for the efficient diagnosis and treatment of many serious diseases. This report addresses the design and synthesis of upconversion magnetic NaGdF4:Yb3+/Er3+(Tm3+) nanoparticles by an oleic acid-stabilized high-temperature coprecipitation of lanthanide precursors in octadec-1-ene. The nanoparticles, which emit visible or UV light under near-infrared (NIR) irradiation, were modified by in-house synthesized PEG-neridronate to facilitate their dispersibility and colloidal stability in water and bioanalytically relevant phosphate buffered saline (PBS). The cytotoxicity of the nanoparticles was determined using HeLa cells and human fibroblasts (HF). Subsequently, the particles were modified by Bolton-Hunter-neridronate and radiolabeled by 125I to monitor their biodistribution in mice using single-photon emission computed tomography (SPECT). The upconversion and the paramagnetic properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles were evaluated by photoluminescence, magnetic resonance (MR) relaxometry, and magnetic resonance imaging (MRI) with 1 T and 4.7 T preclinical scanners. MRI data were obtained on phantoms with different particle concentrations and during pilot long-time in vivo observations of a mouse model. The biological and physicochemical properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles make them promising as a trimodal optical/MRI/SPECT bioimaging and theranostic nanoprobe for experimental medicine.
    PracovištěÚstav makromolekulární chemie
    KontaktEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Rok sběru2021
    Elektronická adresahttps://www.nature.com/articles/s41598-020-77112-z
Počet záznamů: 1