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Human metabolite-derived alkylsuccinate/dilinoleate copolymers: from synthesis to application
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SYSNO ASEP 0534436 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Human metabolite-derived alkylsuccinate/dilinoleate copolymers: from synthesis to application Tvůrce(i) Jäger, Alessandro (UMCH-V) RID, ORCID
Donato, Ricardo Keitel (UMCH-V) ORCID
Perchacz, Magdalena (UMCH-V) RID
Donato, Katarzyna Zawada (UMCH-V)
Starý, Zdeněk (UMCH-V) RID
Konefal, Rafal (UMCH-V) RID, ORCID
Serkis-Rodzen, Magdalena (UMCH-V) RID
Raucci, M. G. (IT)
Fuentefria, A. M. (BR)
Jäger, Eliezer (UMCH-V) ORCID, RIDZdroj.dok. Journal of Materials Chemistry B - ISSN 2050-750X
Roč. 8, č. 43 (2020), s. 9980-9996Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova biocompatible ; biodegradable ; polyesters Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP LO1507 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GJ20-13946Y GA ČR - Grantová agentura ČR GJ20-15077Y GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000588549200015 EID SCOPUS 85096033832 DOI 10.1039/D0TB02068K Anotace The advances in polymer chemistry have allowed the preparation of biomedical polymers using human metabolites as monomers that can hold unique properties beyond the required biodegradability and biocompatibility. Herein, we demonstrate the use of endogenous human metabolites (succinic and dilinoleic acids) as monomeric building blocks to develop a new series of renewable resource-based biodegradable and biocompatible copolyesters. The novel copolyesters were characterized in detail employing several standard techniques, namely 1H NMR, 13C NMR, and FTIR spectroscopy and SEC, followed by an in-depth thermomechanical and surface characterization of their resulting thin films (DSC, TGA, DMTA, tensile tests, AFM, and contact angle measurements). Also, their anti-fungal biofilm properties were assessed via an anti-fungal biofilm assay and the biological properties were evaluated in vitro using relevant human-derived cells (human mesenchymal stem cells and normal human dermal fibroblasts). These novel highly biocompatible polymers are simple and cheap to prepare, and their synthesis can be easily scaled-up. They presented good mechanical, thermal and anti-fungal biofilm properties while also promoting cell attachment and proliferation, outperforming well-known polymers used for biomedical applications (e.g. PVC, PLGA, and PCL). Moreover, they induced morphological changes in the cells, which were dependent on the structural characteristics of the polymers. In addition, the obtained physicochemical and biological properties can be design-tuned by the synthesis of homo- and -copolymers through the selection of the diol moiety (ES, PS, or BS) and by the addition of a co-monomer, DLA. Consequently, the copolyesters presented herein have high application potential as renewable and cost-effective biopolymers for various biomedical applications. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2021 Elektronická adresa https://pubs.rsc.org/en/content/articlelanding/2020/TB/D0TB02068K#!divAbstract
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