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Applications of Nanobiotechnology
- 1.
SYSNO ASEP 0534391 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers Tvůrce(i) Bačáková, Lucie (FGU-C) RID, ORCID
Zikmundová, Markéta (FGU-C)
Pajorová, Julia (FGU-C)
Brož, Antonín (FGU-C) RID, ORCID, SAI
Filová, Elena (FGU-C) RID, ORCID
Blanquer, Andreu (FGU-C) RID, ORCID
Matějka, Roman (FGU-C) RID, ORCID, SAI
Štěpanovská, Jana (FGU-C) ORCID, RID
Mikeš, P. (CZ)
Jenčová, V. (CZ)
Kuželová Košťáková, E. (CZ)
Sinica, A. (CZ)Zdroj.dok. Applications of Nanobiotechnology. - London : IntechOpen, 2020 / Stoytcheva Margarita ; Zlatev Roumen - ISBN 978-1-78985-978-2 Rozsah stran s. 1-29 Poč.str. 29 s. Poč.str.knihy 140 Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova skin replacements ; wound dressings ; nanofibers ; electrospinning ; epidermis ; dermis ; keratinocytes ; fibroblasts ; stem cells ; vascularization ; cell delivery ; drug delivery ; regenerative medicine Vědní obor RIV EI - Biotechnologie a bionika Obor OECD Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction) CEP GA17-02448S GA ČR - Grantová agentura ČR NV18-01-00332 GA MZd - Ministerstvo zdravotnictví Institucionální podpora FGU-C - RVO:67985823 DOI 10.5772/intechopen.88744 Anotace Nanofibrous scaffolds are popular materials in all areas of tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. In this chapter, we focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is an organ with several vitally important functions, particularly barrier, thermoregulatory, and sensory functions. Nanofibrous meshes not only serve as carriers for skin cells but also can prevent the penetration of microbes into wounds and can keep appropriate moisture in the damaged skin. The nanofibrous meshes have been prepared from a wide range of synthetic and nature-derived polymers. This review is concentrated on synthetic non-degradable and degradable polymers, which have been explored for skin tissue engineering and wound healing. These synthetic polymers were often combined with natural polymers of the protein or polysaccharide nature, which improved their attractiveness for cell colonization. The nanofibrous scaffolds can also be loaded with various bioactive molecules, such as growth factors, hormones, vitamins, antioxidants, antimicrobial, and antitumor agents. In advanced tissue engineering approaches, the cells on the nanofibrous scaffolds are cultured in dynamic bioreactors enabling appropriate mechanical stimulation of cells and at air-liquid interface. This chapter summarizes recent results achieved in the field of nanofiber-based skin tissue engineering, including results of our research group. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2021 Elektronická adresa https://www.intechopen.com/books/applications-of-nanobiotechnology/nanofibrous-scaffolds-for-skin-tissue-engineering-and-wound-healing-based-on-synthetic-polymers
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