Počet záznamů: 1  

Phytochemical composition and in vitro biological activity of iris spp. (iridaceae): A new source of bioactive constituents for the inhibition of oral bacterial biofilms

  1. 1.
    SYSNO ASEP0533874
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevPhytochemical composition and in vitro biological activity of iris spp. (iridaceae): A new source of bioactive constituents for the inhibition of oral bacterial biofilms
    Tvůrce(i) Hoang, L. (CZ)
    Beneš, F. (CZ)
    Fenclová, M. (CZ)
    Kronusová, O. (CZ)
    Švarcová, V. (CZ)
    Řehořová, K. (CZ)
    Baldassarre Švecová, Eva (BU-J) ORCID
    Vosátka, Miroslav (BU-J) ORCID
    Hajšlová, J. (CZ)
    Kaštánek, P. (CZ)
    Viktorová, J. (CZ)
    Ruml, T. (CZ)
    Číslo článku403
    Zdroj.dok.Antibiotics (Basel). - : MDPI - ISSN 2079-6382
    Roč. 9, č. 7 (2020), s. 1-20
    Poč.str.20 s.
    Jazyk dok.eng - angličtina
    Země vyd.CH - Švýcarsko
    Klíč. slovabiofilm ; dental plaque ; quorum sensing ; microbial resistance
    Vědní obor RIVCC - Organická chemie
    Obor OECDOrganic chemistry
    Způsob publikováníOpen access
    Institucionální podporaBU-J - RVO:67985939
    UT WOS000557172400001
    EID SCOPUS85087806912
    DOI10.3390/antibiotics9070403
    AnotaceThe publication reported on the chemical composition and the antibiofilm activity of 15 methanolic extracts of Iris species against both mono-(Pseudomonas aeruginosa, Staphylococcus aureus) and multi-species oral biofilms (Streptococcus gordonii, Veillonella parvula, Fusobacterium nucleatum subsp. nucleatum, and Actinomyces naeslundii). The phytochemical profiles of Iris pallida s.l., Iris versicolor L., Iris lactea Pall., Iris carthaliniae Fomin, and Iris germanica were determined by ultra-high performance liquid chromatography-high-resolution tandem mass spectroscopy (UHPLC-HRMS/MS) analysis, and a total of 180 compounds were identified among Iris species with (iso)flavonoid dominancy. I. pallida, I. versicolor, and I. germanica inhibited both the quorum sensing and adhesion during biofilm formation in a concentration-dependent manner. However, the extracts were less active against maturated biofilms. Of the five tested species, Iris pallida s.l. was the most effective at both inhibiting biofilm formation and disrupting existing biofilms, and the leaf extract exhibited the strongest inhibitory effect compared to the root and rhizome extracts. The cytotoxicity of the extracts was excluded in human fibroblasts. The inhibition of bacterial adhesion significantly correlated with myristic acid content, and quorum sensing inhibition correlated with the 7-β-hydroxystigmast-4-en-3-one content. These findings could be useful for establishing an effective tool for the control of oral biofilms and thus dental diseases.
    PracovištěBotanický ústav
    KontaktMartina Bartošová, martina.bartosova@ibot.cas.cz, ibot@ibot.cas.cz, Tel.: 271 015 242 ; Marie Jakšová, marie.jaksova@ibot.cas.cz, Tel.: 384 721 156-8
    Rok sběru2021
    Elektronická adresahttps://doi.org/10.3390/antibiotics9070403
Počet záznamů: 1  

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