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The first chiral HPLC separation of dicarba-nido-undecarborate anions and their chromatographic behavior
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SYSNO ASEP 0532684 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The first chiral HPLC separation of dicarba-nido-undecarborate anions and their chromatographic behavior Tvůrce(i) Horáček, O. (CZ)
Papajová-Janetková, M. (CZ)
Grüner, Bohumír (UACH-T) RID, SAI, ORCID
Lochman, L. (CZ)
Štěrbová-Kovaříková, P. (CZ)
Vespalec, Radim (BFU-R) RID, ORCID
Kučera, R. (CZ)Celkový počet autorů 7 Číslo článku 121652 Zdroj.dok. Talanta. - : Elsevier - ISSN 0039-9140
Roč. 222, JAN (2021)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Carboranes ; Chiral separation ; Chromatography ; Cyclodextrin ; Ion interactions Vědní obor RIV CA - Anorganická chemie Obor OECD Inorganic and nuclear chemistry Vědní obor RIV – spolupráce Biofyzikální ústav - Biofyzika CEP GA19-04630S GA ČR - Grantová agentura ČR Způsob publikování Open access s časovým embargem (15.01.2023) Institucionální podpora UACH-T - RVO:61388980 ; BFU-R - RVO:68081707 UT WOS 000589941600011 EID SCOPUS 85091334743 DOI 10.1016/j.talanta.2020.121652 Anotace Boron cluster compounds are extensively studied due to their possible use in medicinal chemistry, mainly in the boron neutron capture anticancer therapy and as new innovative pharmacophores. Concerning this research, the chiral separations of exceptionally stable anionic 7,8-dicarba-nido-undecaborate(1-) and metal bis(dicarbollide(1-) derivatives with asymmetric substitutions remain the unsolved challenge of the chiral chromatography nowadays. Although the successful enantioseparation of some anionic 7,8-dicarba-nido-undecaborate(1-) ion derivatives were achieved in CZE with native β-cyclodextrins, it has not been observed with HPLC, yet. This study aimed to systematically investigate the enantioseparation of selected compounds in HPLC using native β-cyclodextrin and brominated β-cyclodextrin. The findings revealed positively charged strong adsorption sites on a stationary phase, identified as the cationic metal impurities in the silica-gel backbone. All the anionic species under the study were at least partially enantioseparated when a chelating agent blocked these cationic sites. Consequently, the first-ever HPLC enantioseparations of the 7,8-dicarba-nido-undecaborates(1-) were achieved. The brominated β-cyclodextrin seemed to be a better chiral selector for separation of these species, whereas the native β-cyclodextrin separated the anionic cobalt bis(dicarbollide(1-). The results of this study bring new information concerning the chiral separation of anionic boron clusters and might be used in the chiral method development process on other chiral selectors. Furthermore, the possibility of chiral separation of these species could influence the ongoing research areas of anionic boron clusters. Pracoviště Ústav anorganické chemie Kontakt Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Rok sběru 2022 Elektronická adresa http://hdl.handle.net/11104/0317680
Počet záznamů: 1