Počet záznamů: 1

Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties

SYSNO ASEP	0532310
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties
Tvůrce(i)	Kubát, Pavel (UFCH-W)_{RID, ORCID, SAI} Henke, P. (CZ) Raya, R.K. (CZ) Štěpánek, M. (CZ) Mosinger, Jiří (UACH-T)_{RID, ORCID, SAI}
Zdroj.dok.	Langmuir. - : American Chemical Society - ISSN 0743-7463 Roč. 36, č. 1 (2020), s. 302-310
Poč.str.	9 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	singlet oxygen ; photodynamic therapy ; polymeric nanoparticles ; nanofiber materials ; protein corona ; temperature ; photosensitizers ; delivery ; nanofabrics ; particles
Vědní obor RIV	CF - Fyzikální chemie a teoretická chemie
Obor OECD	Physical chemistry
Vědní obor RIV – spolupráce	Ústav anorganické chemie - Anorganická chemie
CEP	GA19-09721S GA ČR - Grantová agentura ČR
Způsob publikování	Open access s časovým embargem (01.01.2021)
Institucionální podpora	UFCH-W - RVO:61388955 ; UACH-T - RVO:61388980
UT WOS	000507721200034
EID SCOPUS	85077697578
DOI	10.1021/acs.langmuir.9b03468
Anotace	The transport of a photosensitizer to target biological structures followed by the release of singlet oxygen is a critical step in photodynamic therapy. We compared the (photo)physical properties of polystyrene nanoparticles (TPP@PS) of different sizes and self-assembled poly(ethylene glycol)-b-poly(epsilon-caprolactone) core/shell nanoparticles (TPP@PEG-PCL) with different lengths of copolymer blocks, both suitable for the transport of the tetraphenylporphyrin (TPP) photosensitizer. The singlet oxygen was formed inside both nanoparticles after irradiation with visible light. Its kinetics was controlled by the size of TPP@PS, its lifetime (tau(Delta)) increased with increasing nanoparticle size (from 6.5 to 16 mu s) because of hindered diffusion into the external aqueous environment, where it was quickly deactivated. Accordingly, the prolongation of the singlet oxygen-sensitized delayed fluorescence kinetics was found for TPP@PS of high size. The TPP@PEG-PCL self-assemblies allowed for enhanced oxygen diffusion, and the estimated low values of tau(Delta) approximate to 3.7 mu s were independent of the size of building blocks. The delayed fluorescence in oxygen-free conditions originating from triplet-triplet annihilation indicated a high mobility of TPP in the PCL core in comparison with fixed molecules in the PS matrix. Photooxidation of uric acid revealed the highest efficacy for TPP@PS of small sizes, whereas the largest TPP@PS exhibited the lowest activity, and the efficacy of TPP@PEG-PCL remained independent of the sizes of the building blocks.
Pracoviště	Ústav fyzikální chemie J.Heyrovského
Kontakt	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Rok sběru	2021
Elektronická adresa	http://hdl.handle.net/11104/0310832

Počet záznamů: 1