Počet záznamů: 1
Implant-forming polymeric 19F MRI-tracer with tunable dissolution
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SYSNO ASEP 0531966 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Implant-forming polymeric 19F MRI-tracer with tunable dissolution Tvůrce(i) Kolouchouvá, K. (CZ)
Jirák, D. (CZ)
Groborz, Ondřej (UOCHB-X) ORCID, RID
Sedláček, O. (CZ)
Ziolkowska, N. (CZ)
Vít, M. (CZ)
Sticová, E. (CZ)
Gálisová, A. (CZ)
Švec, P. (CZ)
Trousil, J. (CZ)
Hájek, M. (CZ)
Hrubý, M. (CZ)Zdroj.dok. Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 327, Nov 10 (2020), s. 50-60Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova polymer implant ; 19F magnetic resonance imaging ; double-stimuli responsivity ; tunable dissolution Vědní obor RIV CC - Organická chemie Obor OECD Organic chemistry Způsob publikování Omezený přístup Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000585933700006 EID SCOPUS 85089267901 DOI 10.1016/j.jconrel.2020.07.026 Anotace Magnetic resonance imaging (MRI) using 19F-based tracers has emerged as a promising multi-purpose noninvasive diagnostic tool and its application requires the use of various 19F-based tracers for the intended diagnostic purpose. In this study, we report a series of double-stimuli-responsive polymers for use as injectable implants, which were designed to form implants under physiological conditions, and to subsequently dissolve with different dissolution rates (t1/2 ranges from 30 to more than 250 days). Our polymers contain a high concentration of fluorine atoms, providing remarkable signal detectability, and both a hydrophilic monomer and a pH-responsive monomer that alter the biodistribution properties of the implant. The implant location and dissolution were observed using 19F MRI, which allows the anatomic extent of the implant to be monitored. The dissolution kinetics and biocompatibility of these materials were thoroughly analyzed. No sign of toxicity in vitro or in vivo or pathology in vivo was observed, even in chronic administration. The clinical applicability of our polymers was further confirmed via imaging of a rat model by employing an instrument currently used in human medicine. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2021 Elektronická adresa https://doi.org/10.1016/j.jconrel.2020.07.026
Počet záznamů: 1