Počet záznamů: 1
Quantification of volatile metabolites in exhaled breath by selected ion flow tube mass spectrometry, SIFT-MS
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SYSNO ASEP 0531420 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Quantification of volatile metabolites in exhaled breath by selected ion flow tube mass spectrometry, SIFT-MS Tvůrce(i) Španěl, Patrik (UFCH-W) RID, ORCID
Smith, D. (GB)Zdroj.dok. Clinical mass spectrometry. - : Elsevier - ISSN 2376-9998
Roč. 16, APR 2020 (2020), s. 18-24Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova trace gas-analysis ; total-body water ; organic-compounds ; healthy-volunteers ; bowel-disease ; reagent ions ; online ; headspace ; series ; h3o+ ; sift-ms ; Breath VOCs ; Metabolites ; Biomarkers Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry Způsob publikování Omezený přístup Institucionální podpora UFCH-W - RVO:61388955 UT WOS 000539276700003 EID SCOPUS 85079896166 DOI 10.1016/j.clinms.2020.02.001 Anotace Selected ion flow tube mass spectrometry, SIFT-MS, is a non-separative method for direct quantitative analyses of volatile compounds, VOCs, in air and humid breath based on chemical ionization. Selected reagent ions, either H3O+, NO+ or O-2(+) (non-reactive with major components of air), ionize analyte molecules during a defined time in a flow tube by ion-molecule reactions thus producing analyte ions that are characteristic of the neutral analyte VOCs. Concentrations can be calculated in real-time from the ion count rates. Direct on-line analysis of single or multiple breath exhalations or off-line analysis of breath samples collected into bags can be performed. Several volatile breath metabolites have been quantified by SIFT-MS, including ammonia, acetone, hydrogen cyanide, alcohols, pentane, acetic acid, methane, and sulphur compounds. Their potential as biomarkers is discussed. (C) 2020 Published by Elsevier B.V. on behalf of The Association for Mass Spectrometry: Applications to the Clinical Lab (MSACL). Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2021 Elektronická adresa http://hdl.handle.net/11104/0310084
Počet záznamů: 1