Počet záznamů: 1
Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2
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SYSNO ASEP 0525100 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2 Tvůrce(i) Novotný, Jiří (UMG-J) ORCID
Bandurova, V. (CZ)
Strnad, Hynek (UMG-J) RID
Chovanec, M. (CZ)
Hradilová, Miluše (UMG-J)
Šáchová, Jana (UMG-J)
Steffl, M. (CZ)
Grušanovič, Josipa (MBU-M)
Kodet, R. (CZ)
Pačes, Václav (UMG-J) RID
Lacina, L. (CZ)
Smetana, K. , Jr. (CZ)
Plzák, J. (CZ)
Kolář, Michal (UMG-J) RID, ORCID
Vomastek, Tomáš (MBU-M) RID, ORCIDCelkový počet autorů 15 Číslo článku 792 Zdroj.dok. Cancers (Basel). - : MDPI
Roč. 12, č. 4 (2020)Poč.str. 19 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova human papillomavirus ; head and neck squamous cell carcinoma ; cell cycle ; D-type cyclins ; ccnd1 ; ccnd2 ; ccnd3 ; patient survival ; paired tumor-normal samples ; 11q13 amplification Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology Vědní obor RIV – spolupráce Genetika a molekulární biologie
Mikrobiologický ústav - Onkologie a hematologieCEP GA18-11908S GA ČR - Grantová agentura ČR NV16-29032A GA MZd - Ministerstvo zdravotnictví EF16_019/0000785 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UMG-J - RVO:68378050 ; MBU-M - RVO:61388971 UT WOS 000535587400022 DOI 10.3390/cancers12040792 Anotace Aberrant regulation of the cell cycle is a typical feature of all forms of cancer. In head and neck squamous cell carcinoma (HNSCC), it is often associated with the overexpression of cyclin D1 (CCND1). However, it remains unclear how CCND1 expression changes between tumor and normal tissues and whether human papillomavirus (HPV) affects differential CCND1 expression. Here, we evaluated the expression of D-type cyclins in a cohort of 94 HNSCC patients of which 82 were subjected to whole genome expression profiling of primary tumors and paired normal mucosa. Comparative analysis of paired samples showed that CCND1 was upregulated in 18% of HNSCC tumors. Counterintuitively, CCND1 was downregulated in 23% of carcinomas, more frequently in HPV-positive samples. There was no correlation between the change in D-type cyclin expression and patient survival. Intriguingly, among the tumors with downregulated CCND1, one-third showed an increase in cyclin D2 (CCND2) expression. On the other hand, one-third of tumors with upregulated CCND1 showed a decrease in CCND2. Collectively, we have shown that CCND1 was frequently downregulated in HNSCC tumors. Furthermore, regardless of the HPV status, our data suggested that a change in CCND1 expression was alleviated by a compensatory change in CCND2 expression. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2021 Elektronická adresa https://www.mdpi.com/2072-6694/12/4/792
Počet záznamů: 1