Počet záznamů: 1
Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women
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SYSNO ASEP 0524170 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women Tvůrce(i) Březinová, Marie (FGU-C) ORCID
Čajka, Tomáš (FGU-C) RID, ORCID, SAI
Oseeva, Marina (FGU-C) ORCID, RID
Štěpán, M. (CZ)
Daďová, K. (CZ)
Rossmeislová, L. (CZ)
Matouš, M. (CZ)
Šiklová, M. (CZ)
Rossmeisl, Martin (FGU-C) RID, ORCID
Kuda, Ondřej (FGU-C) RID, ORCID, SAIČíslo článku 158576 Zdroj.dok. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. - : Elsevier - ISSN 1388-1981
Roč. 1865, č. 2 (2020)Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova lipidomics ; mass spectrometry ; exercise ; omega-3 fatty acids ; adipose tissue ; PAHSA ; FAHFA ; lipokine ; elderly women ; ether lipids ; FAHFA-TG Vědní obor RIV FB - Endokrinologie, diabetologie, metabolizmus, výživa Obor OECD Endocrinology and metabolism (including diabetes, hormones) CEP NV16-29182A GA MZd - Ministerstvo zdravotnictví LTAUSA17173 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GJ17-10088Y GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000509816500022 EID SCOPUS 85075263746 DOI 10.1016/j.bbalip.2019.158576 Anotace Adverse effects of aging can be delayed with life-style interventions. We examined how exercise training (ET) alone or combined with omega-3 polyunsaturated fatty acid (PUFA) affects serum and adipose tissue (AT) lipidome in older women. Fifty-five sedentary older women were included in the physical activity program and given either sunflower (Placebo) or wax esters-rich (Calanus) oil capsules for 4 months. Serum and subcutaneous abdominal AT samples were acquired while maximum rates of oxygen consumption (VO2 max), insulin sensitivity (hyperinsulinemic-euglycemic clamps) and comprehensive lipidome profiles were determined before and after the study. ET increased VO2 max in both groups. Lipidomics profiling revealed unusual serum triacylglycerols and phospholipids with ether-bound alkyls in the Calanus group, while ET generally induced shorter-chain triacylglycerols in AT, suggesting increased de novo lipogenesis. The latter was positively associated with whole-body insulin sensitivity. Unexpectedly, insulin-sensitizing lipokines from the family of branched palmitic acid esters of hydroxy stearic acid (PAHSAs) were elevated in both serum and AT after ET, while PAHSAs-containing triacylglycerols were detected in AT. ET stimulated beneficial changes in AT, including PAHSAs synthesis. Although the added value of omega-3 PUFA supplementation was not proven, our discovery can help understand the nature of the metabolic benefits of exercise. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2021 Elektronická adresa https://doi.org/10.1016/j.bbalip.2019.158576
Počet záznamů: 1